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Table 3 Comorbidity profile of patients with dementia with Lewy bodies ( n = 634) versus Alzheimer’s disease patients ( n = 9,161) within different subgroups regarding gender, cognitive level at the time of diagnosis and living place using the chapters of the International Statistical Classification of Diseases and Related Health Problems, 10th Revision

From: Comorbidity profile in dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry

Title Gender DLB (%) AD (%) Pvalue Cognition DLB (%) AD (%) Pvalue Living place DLB (%) AD (%) Pvalue
Certain infectious and parasitic diseases Male 14.9 12.5 0.183 MMSE≥22 16.3 11.2 0.005 Own house 14.3 11.4 0.038
Female 11.9 11.1 0.703 MMSE≤22 11.9 12.2 0.855 Nursing home 9.3 15.0 0.188
Neoplasms Male 35.6 33.8 0.494 MMSE≥22 32.8 31.6 0.652 Own house 32.4 30.1 0.259
Female 26.6 27.7 0.701 MMSE≤22 31.9 27.9 0.169 Nursing home 29.3 25.4 0.467
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Male 5.2 4.8 0.687 MMSE≥22 3.6 4.5 0.447 Own house 4.7 4.6 0.967
Female 3.6 4.7 0.403 MMSE≤22 5.9 4.8 0.414 Nursing home 4.0 6.8 0.457
Endocrine, nutritional and metabolic diseases Male 12.8 10.9 0.262 MMSE≥22 10.5 11.7 0.526 Own house 12.3 11.8 0.700
Female 11.9 12.4 0.819 MMSE≤22 15.9 11.8 0.046 Nursing home 13.3 13.5 0.973
Mental and behavioral disorders Male 67.3 37.4 <0.001 MMSE≥22 65.7 40.8 <0.001 Own house 65.5 38.8 <0.001
Female 64.3 39.3 <0.001 MMSE≤22 66.7 36.0 <0.001 Nursing home 70.7 36.5 <0.001
Diseases of the nervous system Male 91.4 72.8 <0.001 MMSE≥22 89.5 75.5 <0.001 Own house 88.7 72.2 <0.001
Female 82.9 70.1 <0.001 MMSE≤22 86.3 66.8 <0.001 Nursing home 82.7 52.3 <0.001
Diseases of the eye and adnexa Male 56.5 44.2 <0.001 MMSE≥22 60.2 49.0 <0.001 Own house 58.3 47.7 <0.001
Female 59.9 49.9 0.002 MMSE≤22 55.6 47.0 0.007 Nursing home 54.7 52.0 0.660
Diseases of the ear and mastoid process Male 15.4 17.2 0.383 MMSE≥22 17.5 17.1 0.857 Own house 15.7 16.2 0.790
Female 14.7 15.3 0.794 MMSE≤22 14.1 14.6 0.819 Nursing home 10.7 12.9 0.588
Diseases of the circulatory system Male 45.8 43.5 0.391 MMSE≥22 43.7 40.8 0.296 Own house 46.3 40.2 0.005
Female 46.8 38.6 0.009 MMSE≤22 49.6 39.1 0.001 Nursing home 45.3 41.2 0.499
Diseases of the respiratory system Male 27.7 20.5 0.001 MMSE≥22 22.0 17.6 0.043 Own house 22.9 18.0 0.004
Female 15.9 16.9 0.677 MMSE≤22 24.4 18.6 0.018 Nursing home 24.0 20.1 0.438
Diseases of the digestive system Male 41.6 37.0 0.079 MMSE≥22 36.7 34.3 0.357 Own house 37.7 32.7 0.013
Female 31.0 29.9 0.721 MMSE≤22 38.9 30.3 0.003 Nursing home 34.7 27.9 0.229
Diseases of the skin and subcutaneous tissue Male 24.3 20.2 0.057 MMSE≥22 25.3 22.5 0.230 Own house 24.7 21.1 0.043
Female 24.6 21.3 0.217 MMSE≤22 24.1 19.3 0.056 Nursing home 22.7 18.6 0.397
Diseases of the musculoskeletal system and connective tissue Male 39.8 36.1 0.157 MMSE≥22 41.3 42.9 0.555 Own house 42.9 41.0 0.371
Female 48.0 43.2 0.132 MMSE≤22 45.6 38.5 0.022 Nursing home 44.0 37.5 0.280
Diseases of the genitourinary system Male 36.4 32.1 0.093 MMSE≥22 38.0 33.6 0.108 Own house 38.3 32.6 0.005
Female 37.3 32.8 0.138 MMSE≤22 35.6 31.1 0.132 Nursing home 25.3 32.6 0.205
Pregnancy, childbirth and the puerperium Male – – – MMSE≥22 0.3 0 0.062 Own house 0.2 0 0.061
Female 0.4 0 0.117 MMSE≤22 0 0.1 1 Nursing home 0 0.4 1
Certain conditions originating in the perinatal period Male 0 0 – MMSE≥22 0 0 – Own house 0 0 –
Female 0 0 – MMSE≤22 0 0 – Nursing home 0 0 –
Congenital malformations, deformations and chromosomal abnormalities Male 1.0 0.6 0.300 MMSE≥22 0.9 0.6 0.464 Own house 0.7 0.5 0.545
Female 0.4 0.6 1 MMSE≤22 0.7 0.4 0.349 Nursing home 1.3 2.1 1
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Male 72.8 66.9 0.020 MMSE≥22 74.1 67.2 0.010 Own house 72.3 64.5 <0.001
Female 72.2 63.0 0.003 MMSE≤22 71.5 61.3 0.001 Nursing home 74.7 62.7 0.043
Injury, poisoning and certain other consequences of external causes Male 50.8 45.1 0.034 MMSE≥22 59.6 49.2 <0.001 Own house 58.3 50.2 <0.001
Female 69.4 54.3 <0.001 MMSE≤22 56.7 53.5 0.312 Nursing home 57.3 64.8 0.206
External causes of morbidity and mortality Male 0 0 – MMSE≥22 0 0 – Own house 0 0 –
Female 0 0 – MMSE≤22 0 0 – Nursing home 0 0 –
Factors influencing health status and contact with health services Male 81.4 73.0 <0.001 MMSE≥22 84.3 76.8 0.001 Own house 83.2 73.8 <0.001
Female 84.1 73.5 <0.001 MMSE≤22 81.1 69.8 <0.001 Nursing home 77.3 65.8 0.047
  1. Statistically significant differences (P≤0.05) in bold. Univariate comparisons were performed using either the chi-square or Fisher’s exact test wherever appropriate. AD, Alzheimer’s disease; DLB, dementia with Lewy bodies; MMSE, Mini-Mental State Examination.
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Alzheimer's Research & Therapy

ISSN: 1758-9193