Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an 11C altropane positron emission tomography study

Table 1 Participant characteristics and neuropsychological performance

	PD subjects	DLB subjects	HCS
n	19	10	17
Age (years)	70.1 ± 7.0	72.1 ± 6.2	73.9 ± 6.7
Gender (female/male)	7/12^a	1/9^b	10/7^a
Education (years)	16.4 ± 3.2	16.4 ± 3.5	16.2 ± 2.9
l-Dopamine equivalent dose (mg)	476.2 ± 379.8^c	256.0 ± 280.3	0^d
Hoehn and Yahr stage	2.5 ± 0.4^c	2.25 ± 1.1^c	0^e
Unified Parkinson Disease Rating Scale	20.9 ± 7.4 ^f	30.3 ± 2.9^b	1.2 ± 2.5^e
Duration of motor symptoms (years)	8.6 ± 5.1^a	3.0 ± 0.7^d	-
Mini-Mental State Examination	28.1 ± 2.4^a	19.3 ± 9.2^b	28.9 ± 1.5^a
Clinical Dementia Rating Scale - sum of boxes	0.4 ± 0.6^a	7.2 ± 3.7^b	0.1 ± 0.2^a
Aggregate cognitive domain factors
Executive
Trailmaking Test B (seconds)	112.4 ± 67.7^a	298.8 ± 3.0^b	73.3 ± 27.7^a
Digit Symbol	41.3 ± 9.0^a	14.1 ± 11.1^b	47.8 ± 21.6^a
Episodic memory
Logical Memory I	12.9 ± 5.4^a	5.6 ± 1.5^b	16.5 ± 3.8^a
Logical Memory II	12.1 ± 6.0^a	5.4 ± 4.9^b	16.1 ± 4.1^a
Semantic memory and language
Free Selective Reminding Test	28.8 ± 6.0^a	18.4 ± 10.0^b	32.9 ± 6.2^a
Free and Cued Selective Reminding Test	47.0 ± 1.6	45.3 ± 2.6	46.3 ± 4.0
Boston Naming Test	27.7 ± 1.7^a	23.1 ± 7.9^b	27.9 ± 3.0^a
Letter Fluency	44.9 ± 12.4^a	24.0 ± 14.1^b	52.7 ± 12.2^a
Category Fluency	31.8 ± 6.9^a	13.9 ± 9.5^b	38.9 ± 15.0^a
Visuospatial skills
Visual Form Discrimination Test	28.9 ± 3.5^a	24.7 ± 5.0^b	30.6 ± 2.4

Values presented as mean ± standard deviation. PD, Parkinson disease without dementia; DLB, dementia with Lewy bodies; HCS, healthy control subjects. Significant differences (P<0.05) between groups are indicated as follows: ^adifferent from DLB; ^bdifferent from PD and HCS; ^cdifferent from HCS; ^ddifferent from PD; ^edifferent from PD and DLB; and ^fdifferent from DLB and HCS.

ISSN: 1758-9193