Table 6 Aggregate vascular risk for incident dementia

52.7 ± 4.7

27

Random postload glucose, SBP, DBP, BMI, subscapular skinfold thickness, total cholesterol, and triglycerides

Per 1-unit increase in z-score

1.06 (1.02, 1.10)^a

1.11 (1.05, 1.18)^a

1.06 (0.97, 1.15)^a

1.0 (0.94, 1.06)^a

1.04 (1.00, 1.08)^b

1.09 (1.01, 1.15)^b

1.04 (0.96, 1.14)^b

1.00 (0.94, 1.05)^b

1.05 (1.01, 1.09)^c

1.10 (1.04, 1.17)^c

1.03 (0.94, 1.13)^c

1.00 (0.95, 1.06)^c

1.03 (0.99, 1.07)^d

1.08 (1.01, 1.15)^d

1.03 (0.94, 1.13)^d

0.99 (0.94, 1.06)^d

76.2 ± 5.9

5.5

Self-report history of diabetes, or hypertension, or heart disease, or current smoking

1

1.7 (1.1, 2.6)^e

2

2.5 (1.6, 3.9)^e

≥3

3.4 (2.1, 5.7)^e

81.5 ± 5.0

5.1

Vascular risk profile: SBP ≥160, DBP <70, pulse pressure <70, diabetes, stroke, heart failure

1

1.11 (0.79, 1.58)^f

1.09 (0.75, 1.60)^f

2

1.65 (1.12, 2.42)^f

1.77 (1.16, 2.71)^f

≥3

2.48 (1.46, 4.20)^f

2.66 (1.39, 5.08)^f

Atherosclerosis risk profile: SBP ≥160, diabetes, stroke

1

1.28 (1.00, 1.64)^f

1.33 (1.00, 1.78)^f

≥2

2.13 (1.46, 3.11)^f

2.09 (1.31, 3.34)^f

Hypoperfusion risk profile: DBP <70, pulse pressure <70, heart failure

1

1.15 (0.90, 1.47)^f

1.27 (0.96, 1.69)^f

≥2

1.88 (1.30, 2.70)^f

2.06 (1.31, 3.34)^f

49.6 ± 0.6

29

SBP >140 mmHg, BMI >28, fasting glucose >7 mmol/L, cholesterol >7mmol/L, current smoking

1

1.4 (1.0, 1.9)^g

2.1 (0.9, 4.6)^g

1.3 (0.9, 1.9)^g

0.9 (0.6, 1.5)^g

2

1.7 (1.2, 2.3)^g

2.8 (1.3, 6.2)^g

1.5 (1.0, 2.2)^g

1.2 (0.8, 2.0)^g

≥3

2.1 (1.5, 3.2)^g

5.1 (2.2, 11.9)^g

1.4 (0.9, 1.4)^g

0.5 (0.2, 1.2)^g

71.0 ± 0.6

13

SBP >140 mmHg, BMI >28, fasting glucose >7mmol/L, cholesterol >7mmol/L, current smoking

1

1.8 (1.2, 2.6)^g

4.1 (1.0, 17.7)^g

1.6 (1.1, 2.5)^g

1.3 (0.8, 2.3)^g

2

1.7 (1.1, 2.6)^g

6.8 (1.6, 29.2)^g

1.4 (0.9, 2.2)^g

1.0 (0.6, 1.9)^g

≥3

1.7 (1.0, 2.9)^g

7.7 (1.6, 37.1)^g

1.1 (0.5, 2.1)^g

0.4 (0.1, 1.3)^g