Table 2 Major factors affecting phenotypic variability in mice
From: Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies
Environmental |
   Housing system (type of caging/enrichment) |
   Housing density (number of mice per cage) |
   Handler/Investigator |
   Light cycle |
   Temperature and humidity |
   Noise and vibration |
   Diet |
   Health status |
Biological |
   Age |
   Sex |
   Body condition |
   Genetic drift |
   Genetic background (mixed versus inbred) |
   Type of background strain |
   Transgene copy number |
   Transgene expression level |