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Table 2 Major factors affecting phenotypic variability in mice

From: Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

   Housing system (type of caging/enrichment)
   Housing density (number of mice per cage)
   Light cycle
   Temperature and humidity
   Noise and vibration
   Health status
   Body condition
   Genetic drift
   Genetic background (mixed versus inbred)
   Type of background strain
   Transgene copy number
   Transgene expression level