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Table 4 Characteristics of compounds less sensitive to ethnic influences and better candidates for global trials

From: Globalization of Alzheimer's disease clinical trials

Linear pharmacokinetics
Wide therapeutic dose range
Minimal metabolism or not metabolized by enzymes subject to genetic influences
High bioavailability
Little inter-subject variability in bioavailability
Low protein binding
Limited potential for drug-diet interactions
Limited potential for drug-drug interactions
Limited potential for abuse or inappropriate use
Not a prodrug
  1. Adapted from [1, 3, 23].