Table 4 Characteristics of compounds less sensitive to ethnic influences and better candidates for global trials
Linear pharmacokinetics |
|---|
Wide therapeutic dose range |
Minimal metabolism or not metabolized by enzymes subject to genetic influences |
High bioavailability |
Little inter-subject variability in bioavailability |
Low protein binding |
Limited potential for drug-diet interactions |
Limited potential for drug-drug interactions |
Limited potential for abuse or inappropriate use |
Not a prodrug |