From: Predictors of long-term cognitive outcome in Alzheimer's disease
MMSE | ADAS-coga | |||||||
---|---|---|---|---|---|---|---|---|
Time in months from start of ChEI treatment | 6 | 12 | 36 | 6 | 12 | 36 | ||
Pairs of groups | ||||||||
Males vs femalesb | 0.19 | 0.19 | 0.19 | ADAS-cog score 40 | 0.77 | 0.77 | 0.77 | |
30 | 0.50 | 0.50 | 0.50 | |||||
20 | 0.23 | 0.23 | 0.23 | |||||
Age, 85 vs 65 yearsb | MMSE score 15 | 1.07 | 1.07 | 1.07 | ADAS-cog score 40 | 1.55 | 1.55 | 1.55 |
20 | 0.24 | 0.24 | 0.24 | 30 | 0.95 | 0.95 | 0.95 | |
25 | -0.58 | -0.58 | -0.58 | 20 | 0.36 | 0.36 | 0.36 | |
Age, 85 vs 75 yearsb | MMSE score 15 | 0.53 | 0.53 | 0.53 | ADAS-cog score 40 | 0.78 | 0.78 | 0.78 |
20 | 0.12 | 0.12 | 0.12 | 30 | 0.48 | 0.48 | 0.48 | |
25 | -0.29 | -0.29 | -0.29 | 20 | 0.18 | 0.18 | 0.18 | |
Age, 75 vs 65 yearsb | MMSE score 15 | 0.53 | 0.53 | 0.53 | ADAS-cog score 40 | 0.78 | 0.78 | 0.78 |
20 | 0.12 | 0.12 | 0.12 | 30 | 0.48 | 0.48 | 0.48 | |
25 | -0.29 | -0.29 | -0.29 | 20 | 0.18 | 0.18 | 0.18 | |
Education, 9 vs 15 years | -0.03 | 0.20 | 1.10 | -0.06 | 0.10 | 0.75 | ||
Education, 12 vs 15 years | -0.01 | 0.10 | 0.55 | -0.03 | 0.05 | 0.38 | ||
Education, 9 vs 12 years | -0.01 | 0.10 | 0.55 | -0.03 | 0.05 | 0.38 | ||
APOE ε4, non-carrier vs carrier | ns | ns | ns | 0.27 | 0.27 | 0.27 | ||
NSAIDs/Acetylsalicylic acid therapy, yes vs no | 0.22 | 0.22 | 0.22 | 0.25 | 0.25 | 0.25 | ||
ChEI-dose, 100% vs 50%c | 0.24 | 0.24 | 0.24 | 0.50 | 0.50 | 0.50 |