From: Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease
Therapy | Results | Mitochondrial involvement? |
---|---|---|
Cholinesterase inhibitors | Improves AD symptoms and decreases markers of inflammation | May decrease nitric oxide produced, leading to decreased RNS and ROS |
NMDA receptor antagonists | Improves AD symptoms and decreases ROS production | May decrease amount of ROS produced due to excessive intracellular Ca2+ |
Enhanced clearance of Aβ | May improve cognition | May decrease Aβ-induced mitochondrial dysfunction and ROS generation |
NSAIDs | No consistent results | May reduce inflammation and ROS |
Antioxidants | No consistent results | Can reduce ROS |
Herbal/Natural products | No consistent results | Potentially decreases Aβ, inflammation, and ROS generation |