From: The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
Substrate | Toxicity |
---|---|
APP, APLP1 and APLP2 | Impaired cell-cell signaling, injury recovery, synaptic function, memory |
IL1R2 | Abnormal inflammatory response |
LRP | Impairments in lipid metabolism, degradation of proteases and activation of lysosomal enzymes |
Navβ1-4 | Altered neuronal excitability [76] |
Neuregulin-1 and neuregulin-3 | Impaired remyelination following nerve injury [58] |
PSGL-1 | Altered leukocyte recruitment during innate and adaptive immune response [77] |
ST6Gal I | Hepatopathology, B-cell dysfunction |