Skip to main content

Table 4 Association of senile plaque coverage with APOE, CLU, CR1 and PICALM genotypes

From: CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques

    Sparse SP Moderate SP Frequent SP
  Valid N No SP Sparse SP OR (95% CI) P-value Moderate SP OR (95% CI) P-value Frequent SP OR (95% CI) P-value
APOEε4-1 378 281 (74.3) 51 (13.5) - - 29 (7.7) - - 17 (4.5) - -
APOEε4+ 174 89 (51.1) 39 (22.4) 2.86 (1.73 to 4.74) <0.0001* 32 (18.4) 5.32 (2.81 to 10.06) <0.0001* 14 (8.0) 3.97 (1.76 to 8.94) 0.001*
CLU TT2 329 227 (69.0) 48 (14.6) - - 33 (10.0) - - 21 (6.4) - -
CLU C+ 192 123 (64.1) 37 (19.3) 1.26 (0.76 to 2.09) 0.378 23 (12.0) 1.06 (0.55 to 2.03) 0.873 9 (4.7) 0.68 (0.29 to 1.63) 0.391
CR1 AA2 182 125 (68.7) 22 (12.1) - - 21 (11.5) - - 14 (7.7) - -
CR1 C+ 355 234 (65.9) 65 (18.3) 1.48 (0.85 to 2.58) 0.167 38 (10.7) 0.92 (0.48 to 1.78) 0.807 18 (5.1) 0.62 (0.28 to 1.38) 0.242
PICALM CC2 217 136 (62.7) 33 (15.2) - - 32 (14.7) - - 16 (7.4) - -
PICALM T+ 319 222 (69.6) 54 (16.9) 0.97 (0.58 to 1.60) 0.898 27 (8.5) 0.43 (0.23 to 0.82) 0.010* 16 (5.0) 0.58 (0.26 to 1.26) 0.169
  1. Abbreviations: APOE , Apolipoprotein E; CI, confidence intervals; CLU , Clusterin; CR1, complement component (3b/4b) receptor 1; N, number of cases; OR, odds ratio; PICALM, phosphatidylinositol-binding clathrin assembly protein; SP, senile plaques. No SP was the reference group. Numbers in brackets are percentages, unless otherwise stated. In some cases it was impossible to obtain all variables due to technical difficulties and sample damage.
  2. * Denotes statistically significant values.
  3. 1 Denotes reference group used for statistical analyses. Age was used as a covariate.
  4. 2 Denotes most common homozygous genotype and used as the reference group for statistical analyses. APOEε4 carriership and age were used as covariates.