For debate: substituting placebo controls in long-term Alzheimer's prevention trials

Table 6 Fixed effects of covariates including Aβ42/T-tau in the mixed model for NP-Batt (189 patients)

Fixed effects	Value	Standard error	Degrees of freedom	t value	P value
Intercept	0.19832	0.09375	564	2.115	0.0348
Visit number	-0.07163	0.03346	564	-2.141	0.0327
Aβ42/T-tau	0.00328	0.01535	184	0.213	0.8312
FAQ at baseline	-0.01015	0.00508	184	-1.999	0.0472
ADAScog at baseline	0.00058	0.00463	184	0.125	0.9007
NP-Batt at baseline	0.99973	0.04373	184	22.861	<0.0001
Visit number × (Aβ42/T-tau)	0.02229	0.00548	564	4.065	0.0001
Visit number × ADAScog	-0.00398	0.00146	564	-2.719	0.0067

Aβ42, β-amyloid_1-42; ADAScog, Alzheimer Disease Assessment Scale - cognitive subscale; FAQ, Functional Assessment Questionnaire; NP-Batt, Neuro-Psychological Battery; T-tau, total tau protein.

ISSN: 1758-9193