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Table 1 Different herbs and formulations effective in the treatment of Alzheimer's disease

From: Herbal therapy: a new pathway for the treatment of Alzheimer's disease

Product Composition Design Outcome measure Source
Huperzine A An extract from Lycopodium A 12-week randomized, double-blind, placebo-controlled trial ADAS-cog, MMSE, CIBIC-plus, ADL of patients with mild to moderate AD Zhang and colleagues [7]
Gingko Biloba EGb 761 A 24-week randomized, placebo- controlled, double-blind study MMSE and CGI in patients with mild to moderate AD Mazza and colleagues [4]
Panax ginseng Ginsenosides A 12-week open-label, randomized double-blind, placebo-controlled study ADAS and MMSE scores of AD patients Lee and colleagues [17]
Salvia officinalis Leaf extract containing monoterpene, flavonoids, polyphenol A 4-month, parallel-group, placebo- controlled trial ADAS-cog and CDR in patients with mild to moderate AD Akhondzadeh and colleagues [11]
Ba Wei Di Hunag Wan Powder of Rehmannia with another seven plants mixed with honey An 8-week randomized, double-blind, placebo-controlled trial MMSE and Barthel Index scores in patients with mild to severe dementia Iwasaki and colleagues [15]
Yi-Gan San formula A mixture of seven different rootstock and branches, lyophilized dry extract A 4-week randomized, observer-blind, controlled trial NPI and ADL in patients with mild to severe dementia Iwasaki and colleagues [16]
  1. AD, Alzheimer disease; ADAS-cog, Alzheimer disease assessment scale-cognitive subscale; ADL, activities of daily living; CDR, Clinical Dementia Rating; CGI, Clinical Global Impression; CIBIC-plus, Clinician's Interview-Based Impression of Change plus Caregiver Input; MMSE, mini-mental state examination; NPI, neuropsychiatric Inventory.