Skip to main content

Table 3 Mean (standard deviation) and effect size estimates for domain-specific measures of cognitive function over time in treated and untreated patients with mild–moderate Alzheimer’s disease

From: Treatment effects in multiple cognitive domains in Alzheimer’s disease: a two-year cohort study

Measure Assessment Mean (standard deviation) Effect size
Time Treated Untreated (Cohen’s d)
DRS attention Baseline 34.5 (3.2) 35.1 (2.0)  
  1 year 33.6 (3.9) 33.6 (3.9) 0.50
  2 years 31.7 (5.2) 30.2 (7.8) 0.40
DRS initiation Baseline 29.6 (6.1) 27.2 (6.2)  
  1 year 28.6 (6.5) 25.4 (7.8) 0.51
  2 years 24.6 (9.2) 19.6 (8.7) 0.50
DRS construction Baseline 5.0 (1.2) 5.4 (1.4)  
  1 year 5.0 (1.3) 4.9 (1.8) 0.52
  2 years 4.3 (1.7) 4.4 (2.0)  
DRS conceptualization Baseline 33.3 (5.8) 34.2 (3.8)  
  1 year 34.4 (4.6) 32.0 (6.3) 0.53
  2 years 31.4 (7.1) 27.2 (10.5) 0.60
DRS memory Baseline 16.9 (4.0) 15.8 (4.3)  
  1 year 15.5 (4.2) 14.1 (4.0)  
  2 years 12.3 (5.0) 10.4 (4.1)  
VR2 Baseline 3.4 (5.9) 4.4 (5.6)  
  1 year 3.0 (5.4) 1.6 (3.8)  
  2 years 1.7 (5.4) 1.3 (2.6)  
BDS Baseline 5.3 (2.2) 5.1 (2.5)  
  1 year 4.9 (2.1) 4.5 (2.4) 0.40
  2 years 4.9 (2.5) 3.9 (2.5) 0.50
REY Baseline 25.7 (9.0) 25.5 (10.8)  
  1 year 25.1 (10.1) 21.4 (13.8) 0.5
  2 years 22.1 (10.6) 17.2 (24.2)  
Benton Line Orientation Test Baseline 20.6 (7.6) 19.8 (9.1)  
  1 year 18.8 (9.8) 17.2 (9.7)  
  2 years 17.7 (9.5) 16.1 (10.3)  
WCST Baseline 41.5 (8.3) 36.9 (7.7)  
  1 year 41.3 (8.8) 35.3 (10.3)  
  2 years 36.6 (9.3) 32.6 (10.1)  
Boston Naming Test Baseline 22.2 (5.4) 20.9 (6.3)  
  1 year 20.3 (6.7) 17.5 (7.5) 0.50
  2 years 18.7 (8.3) 13.3 (8.5) 0.60
Semantic Fluency Baseline 12.4 (4.4) 10.1 (4.3)  
  1 year 10.6 (5.1) 7.9 (4.2)  
  2 years 8.9 (4.2) 5.8 (4.0)  
FAS Baseline 31.6 (12.7) 24.8 (11.6)  
  1 year 30.3 (11.6) 21.3 (13.2) 0.73
  2 years 24.0 (11.8) 17.6 (12.1)  
  1. BDS, Backward Digit Span; DRS, Dementia Rating Scale; FAS Controlled Word Association Test; REY, Rey–Osterreith Complex Figure Test; VR2, delayed visual reproduction; WCST Wisconsin Card Sort Test.