Skip to main content

Table 1 Baseline characteristics for treated ( n= 65) and untreated ( n= 65) patients with mild–moderate Alzheimer’s disease

From: Treatment effects in multiple cognitive domains in Alzheimer’s disease: a two-year cohort study

Factor Untreated Treated χ2/ t statistic (df) P valuea
Males/females 32/33 36/29 0.50 (1) 0.50
Age 71.4 ± 8.4 71.9 ± 9.9 0.70 (128) 0.70
Education (years) 13.5 ± 3.5 13.3 ± 3.9 0.50 (128) 0.50
Handedness    0.40 (1) 0.80
Right 60 63
Both 5 2
Handedness 2    0.021 (1) 0.90
Right 32 55
Both 2 3
Symptom duration (years) 3.5 ± 2.3 2.8 ± 2.3 0.11 (128) 0.80
Mini-Mental State Examination 22.4 ± 3.7 23.1 ± 3.6 1.1 (128) 0.30
Dementia Rating Scale 116.8 ± 11.0 118.8 ± 14.3 0.98 (128) 0.32
Disability Assessment for Dementia 78.9 ± 15.9 82.8 ± 17.3 0.10 (128) 0.90
Instrumental activities of daily living 65.9 ± 25.2 72.2 ± 24.6 0.10 (128) 0.92
Basic activities of daily living 95.8 ± 5.9 95.2 ± 9.1 1.90 (128) 0.06
BEHAVE-AD 5.3 ± 3.6 5.6 ± 6.5 0.20 (128) 0.80
Hypertension 24 16 2.3 0.10
Hyperlipidemia 9 11   0.80
Diabetes 4 3   1.00
Smoking    7.4 0.02
Never 42 32
Current 6 2
Previous 17 31
Family history of stroke 10 13   0.65
Cerebrovascular disease 4 8   0.36
Cardiac disease 11 8   0.60
Peripheral vascular disease 5 1   0.21
Chronic respiratory, gastrointestinal and genitourinary disease 36 47 1.90 0.20
Depressive symptoms (not due to primary psychiatric illness) 0 3   0.20
Neurological problems (for example, migraines) 8 14   0.20
Endocrine/metabolic deficiency/infectious diseases 10 7   0.60
Chemical exposure 4 1   0.40
Ear–nose–throat 15 16   1.00
Cancer 7 9   0.80
Musculoskeletal disease 19 25 1.2 0.27
Statins 8 7   1.00
Selective serotonin reuptake inhibitors 9 17   0.12
Cardiovascular 23 19 0.56 0.45
Antithrombotics 22 22 0.0 1.00
Non-steroidal anti inflammatory drugs 4 2   0.68
Antipsychotics 1 0   1.00
Anticonvulsants 3 5   0.72
Diabetes 3 2   1.00
Hormone replacement therapy 8 9   1.00
Thyroid 9 8   1.00
  1. Data presented ± standard deviation unless otherwise stated. Fisher’s exact test was used for cells with counts ≤15. BEHAVE-AD, Behavioural Pathology in Alzheimer's Disease; df, degrees of freedom. aCritical values corrected for multiple comparisons (Holm’s correction) – no significant difference.