Alzheimer's Research & Therapy

Table 3 Summary of significant regression β coefficients with subcortical hyperintensity volumetrics and cognitive domains

From: Subcortical hyperintensity volumetrics in Alzheimer’s disease and normal elderly in the Sunnybrook Dementia Study: correlations with atrophy, executive function, mental processing speed, and verbal memory

			β coefficient	R²	P value
Atrophy, measured by BPF
	AD (n = 265)
		pvSH	−0.14	0.02	0.02
		Education, years	−0.16	0.03	0.009
		MMSE	0.12	0.01	0.06
	NC (n = 100)
		Age	−0.64	0.42	<0.0001
		Sex	0.16	0.04	<0.05
Atrophy, measured by vCSF
	AD (n = 265)
		Total SH	0.31	0.10	<0.0001
		Education, years	0.14	0.02	0.02
		Sex	−0.12	0.02	0.04
	NC (n = 100)
		Age	0.49	0.24	<0.0001
Executive
	AD (n = 223)
		BPF	0.26	0.07	<0.0001
	NC (n = 94)
		Medial middle frontal SH	−0.24	0.07	0.01
		Education, years	0.23	0.06	<0.05
		BPF	0.31	0.10	<0.01
Mental processing speed
	AD (n = 222)
		pvSH	0.17	0.03	0.01
		Age	−0.33	0.08	<0.0001
		BPF	−0.31	0.08	<0.0001
	NC (n = 88)
		Age	0.24	0.06	<0.05
Memory
	AD (n = 236)
		Left temporal SH	−0.13	0.02	<0.05
		Education, years	0.22	0.05	0.001
		BPF	0.30	0.09	<0.0001
	NC (n = 95)
		Education, years	0.25	0.08	<0.01
		Age	−0.40	0.18	<0.0001

AD, patients with Alzheimer’s disease; BPF, brain parenchymal fraction; MMSE, Mini-Mental State Exam; NC, cognitively normal elderly controls; pvSH, periventricular subcortical hyperintensity; SH, subcortical hyperintensity; vCSF, ventricular cerebrospinal fluid.

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ISSN: 1758-9193

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