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Table 3 Summary of significant regression β coefficients with subcortical hyperintensity volumetrics and cognitive domains

From: Subcortical hyperintensity volumetrics in Alzheimer’s disease and normal elderly in the Sunnybrook Dementia Study: correlations with atrophy, executive function, mental processing speed, and verbal memory

    β coefficient R2 P value
Atrophy, measured by BPF    
  AD (n = 265)    
   pvSH −0.14 0.02 0.02
   Education, years −0.16 0.03 0.009
   MMSE 0.12 0.01 0.06
  NC (n = 100)    
   Age −0.64 0.42 <0.0001
   Sex 0.16 0.04 <0.05
Atrophy, measured by vCSF    
  AD (n = 265)    
   Total SH 0.31 0.10 <0.0001
   Education, years 0.14 0.02 0.02
   Sex −0.12 0.02 0.04
  NC (n = 100)    
   Age 0.49 0.24 <0.0001
Executive    
  AD (n = 223)    
   BPF 0.26 0.07 <0.0001
  NC (n = 94)    
   Medial middle frontal SH −0.24 0.07 0.01
   Education, years 0.23 0.06 <0.05
   BPF 0.31 0.10 <0.01
Mental processing speed    
  AD (n = 222)    
   pvSH 0.17 0.03 0.01
   Age −0.33 0.08 <0.0001
   BPF −0.31 0.08 <0.0001
  NC (n = 88)    
   Age 0.24 0.06 <0.05
Memory    
  AD (n = 236)    
   Left temporal SH −0.13 0.02 <0.05
   Education, years 0.22 0.05 0.001
   BPF 0.30 0.09 <0.0001
  NC (n = 95)    
   Education, years 0.25 0.08 <0.01
   Age −0.40 0.18 <0.0001
  1. AD, patients with Alzheimer’s disease; BPF, brain parenchymal fraction; MMSE, Mini-Mental State Exam; NC, cognitively normal elderly controls; pvSH, periventricular subcortical hyperintensity; SH, subcortical hyperintensity; vCSF, ventricular cerebrospinal fluid.