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Table 2 Participant demographics and volumetric imaging statistics

From: Subcortical hyperintensity volumetrics in Alzheimer’s disease and normal elderly in the Sunnybrook Dementia Study: correlations with atrophy, executive function, mental processing speed, and verbal memory

  AD NC P value Cohen’s d effect size
Demographics     
 Number 265 100 - -
 Age, years 72.8 (9.0) 69.5 (8.0) <0.001 0.38
 Sex, number (percentage) female 152 (57) 55 (55) - -
 Education, years 13.8 (3.8) 15.5 (3.0) <0.001 0.47
 MMSE/30a 23.2 (4.5) 29.0 (1.1) <0.05 1.49
Basic tissue volumetrics b     
 ST-TIV 1,211.8 (140.1) 1,227.7 (112.5) n.s. -
 BPF% 73.1 (4.6) 79.0 (3.7) <0.0001 1.35
 GM 509.9 (55.7) 560.8 (45.0) <0.0001 1.35
 WM 363.6 (55.1) 403.1 (52.3) <0.0001 0.92
 sCSF 274.8 (62.5) 224.2 (48.1) <0.0001 1.24
 vCSF 52.9 (27.1) 34.1 (16.2) <0.0001 1.01
SH volumetrics     
 SH, median (IQR) 5.4 (11.0) 2.5 (3.3) <0.01 0.54
 pvSH, median (IQR) 4.5 (9.9) 1.8 (3.0) <0.01 0.51
 dwSH, median (IQR) 0.6 (1.1) 0.3 (0.6) <0.05 0.38
 Lacunar, mm3, median (IQR) 32.8 (155.9) 10.3 (45.0) <0.0001 0.58
  1. Values reported are mean (standard deviation) unless otherwise specified. aAvailable in 97 cognitively normal elderly controls (NC) and 258 Alzheimer’s disease (AD) subjects. bAll volumes expressed in cubic centimeters unless otherwise indicated. BPF, brain parenchymal fraction; dwSH, deep white subcortical hyperintensity; GM, gray matter; IQR, interquartile range; MMSE, Mini-Mental State Exam; n.s., not significant; pvSH, periventricular subcortical hyperintensity; sCSF, sulcal cerebrospinal fluid; SH, subcortical hyperintensity; ST-TIV, supratentorial total intracranial volume; vCSF, ventricular cerebrospinal fluid; WM, white matter.