| |
AD
|
NC
|
P value
|
Cohen’s d effect size
|
|---|
|
Demographics
| | | | |
|
Number
|
265
|
100
|
-
|
-
|
|
Age, years
|
72.8 (9.0)
|
69.5 (8.0)
|
<0.001
|
0.38
|
|
Sex, number (percentage) female
|
152 (57)
|
55 (55)
|
-
|
-
|
|
Education, years
|
13.8 (3.8)
|
15.5 (3.0)
|
<0.001
|
0.47
|
|
MMSE/30a
|
23.2 (4.5)
|
29.0 (1.1)
|
<0.05
|
1.49
|
|
Basic tissue volumetrics
b
| | | | |
|
ST-TIV
|
1,211.8 (140.1)
|
1,227.7 (112.5)
|
n.s.
|
-
|
|
BPF%
|
73.1 (4.6)
|
79.0 (3.7)
|
<0.0001
|
1.35
|
|
GM
|
509.9 (55.7)
|
560.8 (45.0)
|
<0.0001
|
1.35
|
|
WM
|
363.6 (55.1)
|
403.1 (52.3)
|
<0.0001
|
0.92
|
|
sCSF
|
274.8 (62.5)
|
224.2 (48.1)
|
<0.0001
|
1.24
|
|
vCSF
|
52.9 (27.1)
|
34.1 (16.2)
|
<0.0001
|
1.01
|
|
SH volumetrics
| | | | |
|
SH, median (IQR)
|
5.4 (11.0)
|
2.5 (3.3)
|
<0.01
|
0.54
|
|
pvSH, median (IQR)
|
4.5 (9.9)
|
1.8 (3.0)
|
<0.01
|
0.51
|
|
dwSH, median (IQR)
|
0.6 (1.1)
|
0.3 (0.6)
|
<0.05
|
0.38
|
|
Lacunar, mm3, median (IQR)
|
32.8 (155.9)
|
10.3 (45.0)
|
<0.0001
|
0.58
|
- Values reported are mean (standard deviation) unless otherwise specified. aAvailable in 97 cognitively normal elderly controls (NC) and 258 Alzheimer’s disease (AD) subjects. bAll volumes expressed in cubic centimeters unless otherwise indicated. BPF, brain parenchymal fraction; dwSH, deep white subcortical hyperintensity; GM, gray matter; IQR, interquartile range; MMSE, Mini-Mental State Exam; n.s., not significant; pvSH, periventricular subcortical hyperintensity; sCSF, sulcal cerebrospinal fluid; SH, subcortical hyperintensity; ST-TIV, supratentorial total intracranial volume; vCSF, ventricular cerebrospinal fluid; WM, white matter.
