Subcortical hyperintensity volumetrics in Alzheimer’s disease and normal elderly in the Sunnybrook Dementia Study: correlations with atrophy, executive function, mental processing speed, and verbal memory

Table 2 Participant demographics and volumetric imaging statistics

	AD	NC	P value	Cohen’s d effect size
Demographics
Number	265	100	-	-
Age, years	72.8 (9.0)	69.5 (8.0)	<0.001	0.38
Sex, number (percentage) female	152 (57)	55 (55)	-	-
Education, years	13.8 (3.8)	15.5 (3.0)	<0.001	0.47
MMSE/30^a	23.2 (4.5)	29.0 (1.1)	<0.05	1.49
Basic tissue volumetrics ^b
ST-TIV	1,211.8 (140.1)	1,227.7 (112.5)	n.s.	-
BPF%	73.1 (4.6)	79.0 (3.7)	<0.0001	1.35
GM	509.9 (55.7)	560.8 (45.0)	<0.0001	1.35
WM	363.6 (55.1)	403.1 (52.3)	<0.0001	0.92
sCSF	274.8 (62.5)	224.2 (48.1)	<0.0001	1.24
vCSF	52.9 (27.1)	34.1 (16.2)	<0.0001	1.01
SH volumetrics
SH, median (IQR)	5.4 (11.0)	2.5 (3.3)	<0.01	0.54
pvSH, median (IQR)	4.5 (9.9)	1.8 (3.0)	<0.01	0.51
dwSH, median (IQR)	0.6 (1.1)	0.3 (0.6)	<0.05	0.38
Lacunar, mm³, median (IQR)	32.8 (155.9)	10.3 (45.0)	<0.0001	0.58

Values reported are mean (standard deviation) unless otherwise specified. ^aAvailable in 97 cognitively normal elderly controls (NC) and 258 Alzheimer’s disease (AD) subjects. ^bAll volumes expressed in cubic centimeters unless otherwise indicated. BPF, brain parenchymal fraction; dwSH, deep white subcortical hyperintensity; GM, gray matter; IQR, interquartile range; MMSE, Mini-Mental State Exam; n.s., not significant; pvSH, periventricular subcortical hyperintensity; sCSF, sulcal cerebrospinal fluid; SH, subcortical hyperintensity; ST-TIV, supratentorial total intracranial volume; vCSF, ventricular cerebrospinal fluid; WM, white matter.

ISSN: 1758-9193