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Figure 5 | Alzheimer's Research & Therapy

Figure 5

From: First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

Figure 5

Sera from transgenic rats immunised with tau peptide recognised neurofibrillary degeneration in the Alzheimer’s disease brain. Three representative sera obtained from rats immunised with tau peptide recognised neurofibrillary tangles and neuropil threads in the entorhinal cortex of Alzheimer’s disease brain (A)-through (C). In contrast, serum from a rat immunised with adjuvant did not recognise any neurofibrillary pathology (D). Scale bar = 100 μm.

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