DC8E8 significantly reduces the number of neurofibrillary tangles in transgenic mice. Transgenic mice were treated with mock antibody DC51 (A) and (D) and with DC8E8 (B) and (E). Neurofibrillary tangles (NFTs) were visualised with AT8 staining (A) and (B) and with pS214 antibody (D) and (E). Transgenic mice treated with therapeutic antibody DC8E8 showed significantly less tau pathology than mice treated with mock antibody DC51 (C) and (F). * - P < 0.05; *** - P < 0.001; boxes represent 75 percentiles, middle bars represent medians and outer horizontal bars represents data range.