Examples of imaging abnormalities in dementia with Lewy bodies. (A) Dopamine transporter imaging. Both the control and Alzheimer’s disease (AD) subjects display normal dopamine transporter levels in the striatum. The dementia with Lewy bodies (DLB) subject displays reduced uptake in the putamen bilaterally, reflecting nigrostriatal degeneration. (B) Cerebral blood flow imaging. The AD subject shows decreased perfusion compared with control, particularly in the left temporal lobe. The DLB subject also exhibits perfusion deficits, but these are largely confined to posterior regions including the occipital lobes. FP-CIT, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane; HMPAO, exametazime; SPECT, single photon emission computed tomography.