Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics

Table 1 Reported receptors that bind or mediate the toxicity of soluble amyloid-beta oligomers

Reported receptor
Amylin receptor [139]	NMDA receptor [140–144]	Sortilin [145]
P53-Bax cell death pathway [146]	cAMP/PKA/CREB-signaling pathway [147, 148]	Tau protein kinase 1/glycogen synthase kinase-3β [51]
c-Jun N-terminal kinase [149]	α-synuclein [150]	P/Q-type calcium currents [49]
Cyclin-dependent kinase 5 [149]	EphB2 [151]	Dynamin and RhoA [152]
mGluR, mGluR5, mGluR2 [108, 142, 149, 153, 154]	TNFα [155]	Cofilin [140]
p38 mitogen-activated protein kinase [149]	PrP^c[154, 156–159]	Calcineurin [160–162]
α 7-nicotinic receptors [105]	AMPA [160]	Brain-derived neurotrophic factor [131]
Human LilrB2 [163]	Insulin receptor [164]	Sigma 2 receptor [165]
STI1 [156]

ISSN: 1758-9193