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Table 4 Comorbidity and medication risk factors for mortality (multivariate Cox regression analyses)

From: Cerebral inflammation is an underlying mechanism of early death in Alzheimer’s disease: a 13-year cause-specific multivariate mortality study

Risk factors (covariates) Cause of death (dependent variable) Significant variables P value HR (95% CI)
Comorbidities Dementia No significant variables   
  Dementia and related causes Age <0.001 1.31 (1.12–1.53)
  All-cause mortality Age <0.001 1.30 (1.13–1.50)
   Hypertension 0.041 1.34 (1.01–1.78)
Medications Dementia No significant variables   
  Dementia and related causes Age <0.001 1.30 (1.11–1.52)
  All-cause mortality Age 0.001 1.27 (1.10–1.47)
   Cardiovascular drugs 0.024 1.38 (1.04–1.83)
   Antipsychotics/sedatives 0.036 1.36 (1.02–1.81)
  1. Age was converted to a z-score for comparison with the continuous variables shown in Table 3. All comorbidities and medications with a prevalence ≥10% (Table 2), as well as age and sex, were entered into the Cox regression analyses. Comorbidities and medications were entered separately. HR, hazard ratio.