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Table 2 Number of trials for agents with varying mechanisms of action

From: Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

Year registered Symptomatic for cognition Symptomatic for behavior Disease-modifying small molecule Disease-modifying immunotherapy Therapeutic device Stem cells Total
2002 1 3 0 1 0 0 5
2003 5 1 4 0 2 0 12
2004 5 2 6 0 1 0 14
2005 10 3 16 3 0 0 32
2006 12 1 8 4 0 0 25
2007 18 1 17 10 0 0 46
2008 23 1 18 15 4 0 61
2009 31 2 19 17 2 1 72
2010 11 2 23 13 2 0 51
2011 17 2 17 5 3 1 45
2012 18 4 17 8 2 1 50
Total 151 22 145 76 16 3 413
Percent 36.56 5.33 35.11 18.40 3.87 0.73 100