From: Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels
Haplotype | Alleles | Brain region | Freq | ILMN_1710903 | ILMN_2298727 | ILMN_2310814 | |||
---|---|---|---|---|---|---|---|---|---|
BETA | P | BETA | P | BETA | P | ||||
A (H2a) | AGGCGG | CER | 0.212 | -0.45 | 8.7E-33 | -0.16 | 0.003 | 0.00 | 0.832 |
TCX | 0.212 | -0.49 | 1.1E-31 | -0.20 | 0.001 | 0.02 | 0.308 | ||
B (H1b) | GGGCAA | CER | 0.180 | 0.15 | 0.003 | 0.07 | 0.207 | -0.01 | 0.691 |
TCX | 0.180 | 0.13 | 0.026 | 0.13 | 0.058 | 0.01 | 0.630 | ||
C (H1c) | AAGTAG | CER | 0.104 | 0.11 | 0.057 | 0.02 | 0.807 | 0.02 | 0.338 |
TCX | 0.104 | 0.17 | 0.008 | 0.05 | 0.536 | -0.02 | 0.309 | ||
D (H1d) | AAGCAA | CER | 0.057 | 0.00 | 0.970 | 0.04 | 0.721 | 0.07 | 0.098 |
TCX | 0.057 | 0.30 | 0.007 | 0.14 | 0.314 | -0.02 | 0.646 | ||
E (H1e) | AGGCAA | CER | 0.079 | 0.09 | 0.273 | 0.04 | 0.621 | 0.02 | 0.554 |
TCX | 0.079 | 0.15 | 0.079 | 0.13 | 0.212 | 0.00 | 0.964 | ||
H | AGACAA | CER | 0.025 | 0.05 | 0.748 | -0.13 | 0.478 | 0.04 | 0.538 |
TCX | 0.025 | 0.13 | 0.424 | -0.05 | 0.803 | -0.05 | 0.353 | ||
I | GAGCAA | CER | 0.059 | 0.24 | 0.010 | 0.20 | 0.070 | -0.04 | 0.322 |
TCX | 0.059 | 0.07 | 0.422 | -0.09 | 0.434 | -0.01 | 0.766 | ||
L | AGACAG | CER | 0.043 | 0.17 | 0.062 | 0.01 | 0.921 | -0.02 | 0.634 |
TCX | 0.043 | -0.01 | 0.954 | -0.33 | 0.009 | 0.01 | 0.841 | ||
M | GAGCAG | CER | 0.028 | 0.26 | 0.043 | 0.01 | 0.936 | 0.01 | 0.829 |
TCX | 0.028 | 0.16 | 0.298 | -0.23 | 0.204 | 0.00 | 0.927 | ||
O | AAACAA | CER | 0.037 | 0.19 | 0.104 | 0.00 | 0.985 | -0.04 | 0.435 |
TCX | 0.037 | 0.20 | 0.070 | 0.21 | 0.110 | 0.00 | 0.933 | ||
P | GGGTAG | CER | 0.019 | 0.04 | 0.765 | 0.07 | 0.637 | 0.02 | 0.731 |
TCX | 0.019 | 0.07 | 0.725 | 0.26 | 0.259 | -0.03 | 0.613 | ||
T | AGATAG | CER | 0.016 | 0.01 | 0.935 | -0.24 | 0.212 | -0.07 | 0.285 |
TCX | 0.016 | 0.00 | 0.994 | 0.47 | 0.075 | 0.02 | 0.729 | ||
U | AAGCAG | CER | 0.029 | 0.15 | 0.251 | 0.04 | 0.786 | -0.14 | 0.008 |
TCX | 0.029 | 0.35 | 0.008 | 0.25 | 0.112 | -0.01 | 0.836 | ||
X | GAATAG | CER | 0.025 | 0.10 | 0.406 | 0.19 | 0.168 | 0.06 | 0.248 |
TCX | 0.025 | -0.04 | 0.756 | 0.11 | 0.510 | 0.02 | 0.584 | ||
Y* | AAATAG | CER | 0.022 | -0.02 | 0.884 | -0.13 | 0.458 | -0.02 | 0.761 |
TCX | 0.022 | -0.03 | 0.841 | -0.03 | 0.882 | 0.00 | 0.933 | ||
CER | Global p | 3.0E-42 | 0.352 | 0.271 | |||||
TCX | 3.2E-36 | 0.004 | 0.999 |