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Table 4 MAPT haplotype association results with brain MAPT gene expression levels

From: Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

Haplotype Alleles Brain region Freq ILMN_1710903 ILMN_2298727 ILMN_2310814
     BETA P BETA P BETA P
A (H2a) AGGCGG CER 0.212 -0.45 8.7E-33 -0.16 0.003 0.00 0.832
TCX 0.212 -0.49 1.1E-31 -0.20 0.001 0.02 0.308
B (H1b) GGGCAA CER 0.180 0.15 0.003 0.07 0.207 -0.01 0.691
TCX 0.180 0.13 0.026 0.13 0.058 0.01 0.630
C (H1c) AAGTAG CER 0.104 0.11 0.057 0.02 0.807 0.02 0.338
TCX 0.104 0.17 0.008 0.05 0.536 -0.02 0.309
D (H1d) AAGCAA CER 0.057 0.00 0.970 0.04 0.721 0.07 0.098
TCX 0.057 0.30 0.007 0.14 0.314 -0.02 0.646
E (H1e) AGGCAA CER 0.079 0.09 0.273 0.04 0.621 0.02 0.554
TCX 0.079 0.15 0.079 0.13 0.212 0.00 0.964
H AGACAA CER 0.025 0.05 0.748 -0.13 0.478 0.04 0.538
TCX 0.025 0.13 0.424 -0.05 0.803 -0.05 0.353
I GAGCAA CER 0.059 0.24 0.010 0.20 0.070 -0.04 0.322
TCX 0.059 0.07 0.422 -0.09 0.434 -0.01 0.766
L AGACAG CER 0.043 0.17 0.062 0.01 0.921 -0.02 0.634
TCX 0.043 -0.01 0.954 -0.33 0.009 0.01 0.841
M GAGCAG CER 0.028 0.26 0.043 0.01 0.936 0.01 0.829
TCX 0.028 0.16 0.298 -0.23 0.204 0.00 0.927
O AAACAA CER 0.037 0.19 0.104 0.00 0.985 -0.04 0.435
TCX 0.037 0.20 0.070 0.21 0.110 0.00 0.933
P GGGTAG CER 0.019 0.04 0.765 0.07 0.637 0.02 0.731
TCX 0.019 0.07 0.725 0.26 0.259 -0.03 0.613
T AGATAG CER 0.016 0.01 0.935 -0.24 0.212 -0.07 0.285
TCX 0.016 0.00 0.994 0.47 0.075 0.02 0.729
U AAGCAG CER 0.029 0.15 0.251 0.04 0.786 -0.14 0.008
TCX 0.029 0.35 0.008 0.25 0.112 -0.01 0.836
X GAATAG CER 0.025 0.10 0.406 0.19 0.168 0.06 0.248
TCX 0.025 -0.04 0.756 0.11 0.510 0.02 0.584
Y* AAATAG CER 0.022 -0.02 0.884 -0.13 0.458 -0.02 0.761
TCX 0.022 -0.03 0.841 -0.03 0.882 0.00 0.933
   CER Global p 3.0E-42 0.352 0.271
   TCX   3.2E-36 0.004 0.999
  1. Haplotypes with frequencies > 1% are assessed with multivariable linear regression analysis. Alleles for the SNPs defining the haplotypes are given in the 5’ to 3’ order as follows: rs1467967, rs242557, rs3785883, rs2471738, rs8070723, rs7521. Haplotypes not previously observed are designated by an asterisk (*). CER = cerebellum, TCX = temporal cortex. Beta: Coefficient of association with the minor allele. P = p-value.
  2. Boldface values within the tables indicate significant or suggestive associations with a p-value <0.10.