Skip to main content

Table 3 MAPT single SNPs association results with brain MAPT gene expression levels

From: Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

SNP

Brain region

N

ILMN_1710903

ILMN_2298727

ILMN_2310814

   

BETA

P

BETA

P

BETA

P

rs1467967

CER

166

0.16

9.3E-06

0.11

0.011

0.00

0.859

TCX

171

0.15

2.6E-04

0.12

0.019

-0.01

0.604

rs242557

CER

173

0.17

1.2E-05

0.08

0.091

0.01

0.584

TCX

180

0.23

3.4E-08

0.10

0.050

-0.02

0.196

rs3785883

CER

175

0.14

0.005

0.00

0.977

-0.01

0.621

TCX

181

0.03

0.548

-0.07

0.266

0.01

0.706

rs2471738

CER

176

0.07

0.101

0.02

0.665

0.02

0.386

TCX

182

0.11

0.016

0.09

0.089

-0.01

0.397

rs8070723

CER

174

-0.44

2.1E-30

-0.16

0.002

0.01

0.666

TCX

181

-0.48

8.9E-31

-0.20

4.9E-04

0.02

0.222

rs7521

CER

176

0.12

2.8E-04

0.08

0.048

0.00

0.897

 

TCX

182

0.16

1.1E-05

0.08

0.084

0.00

0.976

  1. Results of multivariable linear regression analyses are shown. Probes ILMN_1710903 and ILMN_2310814 anneal to the 3’UTR sequence and ILMN_2298727 targets exon 4a. CER = cerebellum, TCX = temporal cortex. Beta: Coefficient of association with the minor allele. P = p-value.
  2. Boldface values within the tables indicate significant or suggestive associations with a p-value <0.10.