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Table 3 MAPT single SNPs association results with brain MAPT gene expression levels

From: Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

SNP Brain region N ILMN_1710903 ILMN_2298727 ILMN_2310814
    BETA P BETA P BETA P
rs1467967 CER 166 0.16 9.3E-06 0.11 0.011 0.00 0.859
TCX 171 0.15 2.6E-04 0.12 0.019 -0.01 0.604
rs242557 CER 173 0.17 1.2E-05 0.08 0.091 0.01 0.584
TCX 180 0.23 3.4E-08 0.10 0.050 -0.02 0.196
rs3785883 CER 175 0.14 0.005 0.00 0.977 -0.01 0.621
TCX 181 0.03 0.548 -0.07 0.266 0.01 0.706
rs2471738 CER 176 0.07 0.101 0.02 0.665 0.02 0.386
TCX 182 0.11 0.016 0.09 0.089 -0.01 0.397
rs8070723 CER 174 -0.44 2.1E-30 -0.16 0.002 0.01 0.666
TCX 181 -0.48 8.9E-31 -0.20 4.9E-04 0.02 0.222
rs7521 CER 176 0.12 2.8E-04 0.08 0.048 0.00 0.897
  TCX 182 0.16 1.1E-05 0.08 0.084 0.00 0.976
  1. Results of multivariable linear regression analyses are shown. Probes ILMN_1710903 and ILMN_2310814 anneal to the 3’UTR sequence and ILMN_2298727 targets exon 4a. CER = cerebellum, TCX = temporal cortex. Beta: Coefficient of association with the minor allele. P = p-value.
  2. Boldface values within the tables indicate significant or suggestive associations with a p-value <0.10.