Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

Table 1 MAPT single SNPs association results with LOAD risk in the Mayo, ADGC and combined Mayo + ADGC cohorts

SNP	A1	Mayo cohort						ADGC cohort						Mayo + ADGC
		N	MAF_A	MAF_U	OR	95% CI	P	N	MAF_A	MAF_U	OR	95% CI	P	N	MAF_A	MAF_U	OR	95% CI	P
rs1467967	G	4,986	0.335	0.330	1.10	0.99 - 1.22	0.079	14,365	0.329	0.327	1.05	0.99 - 1.11	0.102	19,351	0.330	0.327	1.05	1.00 - 1.10	0.062
rs242557	A	4,935	0.377	0.379	1.00	0.90 - 1.11	0.988	13,407	0.358	0.356	1.01	0.95 - 1.07	0.721	18,342	0.363	0.364	1.00	0.95 - 1.05	0.974
rs3785883	A	5,247	0.182	0.183	1.07	0.95 - 1.22	0.274	15,187	0.178	0.171	1.08	1.01 - 1.15	0.032	20,434	0.179	0.175	1.06	1.01 - 1.13	0.034
rs2471738	T	5,282	0.223	0.209	1.07	0.95 - 1.21	0.250	14,181	0.207	0.201	1.05	0.98 - 1.12	0.194	19,463	0.209	0.203	1.05	0.99 - 1.11	0.109
rs8070723	G	5,129	0.209	0.222	0.81	0.71 - 0.91	7.0E-04	15,895	0.211	0.221	0.89	0.84 - 0.94	1.3E-04	21,024	0.211	0.221	0.90	0.85 - 0.95	5.3E-05
rs7521	A	5,171	0.458	0.457	1.08	0.97 - 1.19	0.152	15,656	0.466	0.468	1.02	0.97 - 1.07	0.529	20,827	0.465	0.465	1.02	0.97 - 1.06	0.437

Results of multivariable logistic regression analyses are shown. CHR = chromosome. A1 = Minor Allele, N = number of subjects with genotype calls, A = Affected (LOAD subjects), U = Unaffected (Control), MAF = Minor Allele Frequency, OR = Odds Ratio, 95% CI = 95% Confidence intervals, P = p-value.
Boldface values within the tables indicate significant or suggestive associations with a p-value <0.10.

ISSN: 1758-9193