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Table 1 MAPT single SNPs association results with LOAD risk in the Mayo, ADGC and combined Mayo + ADGC cohorts

From: Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

SNP A1 Mayo cohort ADGC cohort Mayo + ADGC
   N MAF_A MAF_U OR 95% CI P N MAF_A MAF_U OR 95% CI P N MAF_A MAF_U OR 95% CI P
rs1467967 G 4,986 0.335 0.330 1.10 0.99 - 1.22 0.079 14,365 0.329 0.327 1.05 0.99 - 1.11 0.102 19,351 0.330 0.327 1.05 1.00 - 1.10 0.062
rs242557 A 4,935 0.377 0.379 1.00 0.90 - 1.11 0.988 13,407 0.358 0.356 1.01 0.95 - 1.07 0.721 18,342 0.363 0.364 1.00 0.95 - 1.05 0.974
rs3785883 A 5,247 0.182 0.183 1.07 0.95 - 1.22 0.274 15,187 0.178 0.171 1.08 1.01 - 1.15 0.032 20,434 0.179 0.175 1.06 1.01 - 1.13 0.034
rs2471738 T 5,282 0.223 0.209 1.07 0.95 - 1.21 0.250 14,181 0.207 0.201 1.05 0.98 - 1.12 0.194 19,463 0.209 0.203 1.05 0.99 - 1.11 0.109
rs8070723 G 5,129 0.209 0.222 0.81 0.71 - 0.91 7.0E-04 15,895 0.211 0.221 0.89 0.84 - 0.94 1.3E-04 21,024 0.211 0.221 0.90 0.85 - 0.95 5.3E-05
rs7521 A 5,171 0.458 0.457 1.08 0.97 - 1.19 0.152 15,656 0.466 0.468 1.02 0.97 - 1.07 0.529 20,827 0.465 0.465 1.02 0.97 - 1.06 0.437
  1. Results of multivariable logistic regression analyses are shown. CHR = chromosome. A1 = Minor Allele, N = number of subjects with genotype calls, A = Affected (LOAD subjects), U = Unaffected (Control), MAF = Minor Allele Frequency, OR = Odds Ratio, 95% CI = 95% Confidence intervals, P = p-value.
  2. Boldface values within the tables indicate significant or suggestive associations with a p-value <0.10.