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Table 1 Population demography and biomarker values

From: A diagnostic scale for Alzheimer’s disease based on cerebrospinal fluid biomarker profiles

Paris-1 Paris-2 Lille-1 Lille-2 Montpellier-1 Montpellier-2 RSB
AD n = 118 Mean SD AD n = 41 Mean SD AD n = 118 Mean SD AD n = 73 Mean SD AD n = 129 Mean SD AD n = 142 Mean SD AD n = 213 Mean SD
Age 73.6 8.8 Age 70.9 8.9 Age 68.3 9 Age 67 9.5 Age 69.7 8.8 Age 71.1 10.1 Age 66.3 8.7
Aβ42 440 189 Aβ42 594 238 Aβ42 338 162 Aβ42 603 245 Aβ42 505 224 Aβ42 654 256 Aβ42 420 224
Tau 598 295 Tau 543 279 Tau 608 336 Tau 778 364 Tau 611 327 Tau 702 727 Tau 666 407
p-tau 99 40.4 p-tau 86 34 p-tau 98.1 46.9 p-tau 101.5 41.2 p-tau 85.9 40.2 p-tau 86 37.7 p-tau 92.4 38.1
MMSE 19.4 5.6 MMSE 18.7 6.7 MMSE 18.1 6.5 MMSE 19.6 6.3 MMSE 21.9 5.5 MMSE 20.7 7.4 MMSE 19.0 6.1
Sex (%M) 47%   sex (%M) 65%   sex (%M) 37%   sex (%M) 47%   sex (%M) 47%   sex (%M) 49%   sex (%M) 50%  
NAD n = 53 Mean SD NAD n = 68 Mean SD NAD n = 128 Mean SD NAD n = 51 Mean SD NAD n = 215 Mean SD NAD n = 147 Mean SD NAD n = 195 Mean SD
Age 62.1 13.1 Age 67.4 11.1 Age 67.3 10.7 Age 64.6 10.7 Age 64.1 13.6 Age 63.4 13.6 Age 65.4 10.1
Aβ42 686 243 Aβ42 843 246 Aβ42 494 192 Aβ42 974 355 Aβ42 706 266 Aβ42 999 373 Aβ42 723 346
Tau 253 226 Tau 223 141 Tau 273 197 Tau 284 149 Tau 291 233 Tau 310 241 Tau 339 258
p-tau 48.6 23.1 p-tau 43.5 19.3 p-tau 52.6 28.7 p-tau 46.5 15.8 p-tau 44.8 23.7 p-tau 38.4 18.6 p-tau 49.3 25.8
MMSE 23 5.3 MMSE 23.6 4.9 MMSE 21.3 5.5 MMSE 21. 2 6 MMSE 20.7 7.1 MMSE 21.1 6.9 MMSE 21.0 6.1
Sex (%M) 53%   Sex (%M) 49%   sex (%M) 51%   sex (%M) 59%   sex (%M) 53%   sex (%M) 55%   sex (%M) 51%  
  1. Mean and standard deviation of demographic data, CSF biomarker levels (Aβ42, tau, and p-tau) and Mini Mental Score (MMSE) for the patients with AD or NAD diagnosis in the different centers (Montpellier, Lille, Paris) in two independent cohorts that differed by their collection tubes (−1, −2) and in the three additional PLM centers: Rouen, Strasbourg, and Besançon (RSB).