A diagnostic scale for Alzheimer’s disease based on cerebrospinal fluid biomarker profiles

Table 1 Population demography and biomarker values

Paris-1			Paris-2			Lille-1			Lille-2			Montpellier-1			Montpellier-2			RSB
AD n = 118	Mean	SD	AD n = 41	Mean	SD	AD n = 118	Mean	SD	AD n = 73	Mean	SD	AD n = 129	Mean	SD	AD n = 142	Mean	SD	AD n = 213	Mean	SD
Age	73.6	8.8	Age	70.9	8.9	Age	68.3	9	Age	67	9.5	Age	69.7	8.8	Age	71.1	10.1	Age	66.3	8.7
Aβ42	440	189	Aβ42	594	238	Aβ42	338	162	Aβ42	603	245	Aβ42	505	224	Aβ42	654	256	Aβ42	420	224
Tau	598	295	Tau	543	279	Tau	608	336	Tau	778	364	Tau	611	327	Tau	702	727	Tau	666	407
p-tau	99	40.4	p-tau	86	34	p-tau	98.1	46.9	p-tau	101.5	41.2	p-tau	85.9	40.2	p-tau	86	37.7	p-tau	92.4	38.1
MMSE	19.4	5.6	MMSE	18.7	6.7	MMSE	18.1	6.5	MMSE	19.6	6.3	MMSE	21.9	5.5	MMSE	20.7	7.4	MMSE	19.0	6.1
Sex (%M)	47%		sex (%M)	65%		sex (%M)	37%		sex (%M)	47%		sex (%M)	47%		sex (%M)	49%		sex (%M)	50%
NAD n = 53	Mean	SD	NAD n = 68	Mean	SD	NAD n = 128	Mean	SD	NAD n = 51	Mean	SD	NAD n = 215	Mean	SD	NAD n = 147	Mean	SD	NAD n = 195	Mean	SD
Age	62.1	13.1	Age	67.4	11.1	Age	67.3	10.7	Age	64.6	10.7	Age	64.1	13.6	Age	63.4	13.6	Age	65.4	10.1
Aβ42	686	243	Aβ42	843	246	Aβ42	494	192	Aβ42	974	355	Aβ42	706	266	Aβ42	999	373	Aβ42	723	346
Tau	253	226	Tau	223	141	Tau	273	197	Tau	284	149	Tau	291	233	Tau	310	241	Tau	339	258
p-tau	48.6	23.1	p-tau	43.5	19.3	p-tau	52.6	28.7	p-tau	46.5	15.8	p-tau	44.8	23.7	p-tau	38.4	18.6	p-tau	49.3	25.8
MMSE	23	5.3	MMSE	23.6	4.9	MMSE	21.3	5.5	MMSE	21. 2	6	MMSE	20.7	7.1	MMSE	21.1	6.9	MMSE	21.0	6.1
Sex (%M)	53%		Sex (%M)	49%		sex (%M)	51%		sex (%M)	59%		sex (%M)	53%		sex (%M)	55%		sex (%M)	51%

Mean and standard deviation of demographic data, CSF biomarker levels (Aβ42, tau, and p-tau) and Mini Mental Score (MMSE) for the patients with AD or NAD diagnosis in the different centers (Montpellier, Lille, Paris) in two independent cohorts that differed by their collection tubes (−1, −2) and in the three additional PLM centers: Rouen, Strasbourg, and Besançon (RSB).

ISSN: 1758-9193