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Table 2 Classification accuracy of the cerebrospinal fluid biomarkers

From: Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment

 

AD subjects vs. controls

MCI subjects vs. controls

 

Sensitivity (%)

Specificity (%)

Kappa

AUC

Sensitivity (%)

Specificity (%)

Kappa

AUC

Total tau/Aβ1–42

76.9

86.7

0.64

0.84

59.4

67.9

0.27

0.73

Total tau/Aβ1–42 C3

69.2

93.3

0.64

0.84

50.0

69.8

0.20

0.72

Total tau/Aβ1–42 FH

76.9

86.7

0.64

0.83

59.4

67.9

0.27

0.73

Total tau/Aβ1–42 C3/FH

76.9

86.7

0.64

0.84

56.3

66.0

0.22

0.71

  1. Gender (male reference category) included as a covariate. Aβ1–42, amyloid β peptide 1–42; AD, Alzheimer’s disease; AUC, area under the curve; C3, complement 3; FH, factor H; MCI, mild cognitive impairment.