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Figure 1 | Alzheimer's Research & Therapy

Figure 1

From: Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

Figure 1

Schematic representation of PI3K/AKT/GSK-3β signaling pathway in neuronal cells of Alzheimer’s disease. Examples of molecules known to act on the regulatory pathways are shown. Note that some critical pathways have been omitted for clarity. 5-HT, 5-hydroxytryptamine, serotonin; BDNF, brain-derived neurotrophic factor; CDK5, cyclin-dependent kinase 5; GSK-3β, glycogen synthase kinase-3β; IKK, IκB kinase; NF-κB, nuclear factor-kappa-B; p38-MAPK, p38 mitogen-activated protein kinase; PI3K, phosphoinositide-3 kinase; PP2A, protein phosphatase 2A; TrkB, tropomyosin-receptor-kinase B; TSP1, thrombospondin-1.

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