Skip to main content
Figure 6 | Alzheimer's Research & Therapy

Figure 6

From: β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

Figure 6

Hyperhomocysteinemia induces an inflammatory phenotype shift in the APP/PS1 transgenic mice away from M2a and toward M1. The graph shows fold changes for each gene relative to the wild-type control mice. The dashed line at 1 indicates the normal wild-type expression of these genes. IL, Interleukin; TNF, Tumor necrosis factor; IL1rn, Interleukin 1 receptor antagonist; Arg1, Arginase type 1; TGF, Transforming growth factor; FcgR1, Fc gamma receptor 1 *P < 0.05, **P < 0.01 compared to APP/PS1 control (n = 16 for each wild-type group and n = 20 for each APP/PS1 group). Error bars show SEM.

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193