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Figure 5 | Alzheimer's Research & Therapy

Figure 5

From: β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

Figure 5

CD45 expression by microglial cells is increased by hyperhomocysteinemia in both wild-type and APP/PS1 mice. CD45 immunohistochemical staining in the frontal cortices of wild-type (WT) mice fed the control diet (A) or the hyperhomocysteinemia (HHcy) diet (B) and APP/PS1 mice fed the control diet (C) or the HHcy diet (D). Original magnification = 200×. Scale bar = 25 μm. (E) Quantification of percent area occupied by positive CD45 immunoreactivity in the frontal cortex and hippocampus of WT and APP/PS1 mice on both control (n = 16 for WT and n = 20 for APP/PS1, black bars) and HHcy diet (n = 16 for WT and n = 20 for APP/PS1, white bars). **P < 0.01 compared to the control group for a given genotype. Error bars show SEM.

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Alzheimer's Research & Therapy

ISSN: 1758-9193