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Figure 3 | Alzheimer's Research & Therapy

Figure 3

From: β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

Figure 3

Amyloid is redistributed to the vasculature in the hyperhomocysteinemia APP/PS1 transgenic mice. Congo red staining in the hippocampi of APP/PS1 mice fed the control diet (A) or the hyperhomocysteinemia (HHcy) diet (B). (A) shows the CA1, CA3 and dentate gyrus (DG) for orientation. Scale bar = 120 μm for (A) and (B). (C) Quantification of percent area occupied by positive Congo red staining in the hippocampus and frontal cortex of APP/PS1 transgenic mice on either control (Cont) diet (n = 20, black bars) or the HHcy diet (n = 20, white bars). Each graph shows total Congo red, parenchymal Congo red and cerebral amyloid angiopathy (CAA) Congo red. **P < 0.01 compared to APP/PS1 control. Error bars show SEM.

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Alzheimer's Research & Therapy

ISSN: 1758-9193