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Figure 2 | Alzheimer's Research & Therapy

Figure 2

From: β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

Figure 2

Total β-amyloid is unaltered by hyperhomocysteinemia in APP/PS1 transgenic mice. Total β-amyloid (Aβ) immunohistochemistry in the hippocampus of APP/PS1 mice on either the control diet (A) or the hyperhomocysteinemia (HHcy) diet (B). (A) shows the CA1, CA3 and dentate gyrus (DG) for orientation. Original magnification = 40×. Scale = 120 μm. (C) Quantification of percent area occupied by positive staining for Aβ in the hippocampus (HPC) and frontal cortex (FCX) of APP/PS1 transgenic mice fed either the control diet (n = 20, black bars) or the HHcy diet (n = 20, white bars). Error bars show SEM. (D) Biochemical quantification of Aβ1–38, Aβ1–40 and Aβ1–42 in both the soluble and insoluble protein extracts ± SEM.

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