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Table 2 Residues of the antibody contacting A β (that is, within 4 angstroms) in the structure of 3D6 with A β1-7

From: Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab

Aβ residue Structure VL contacts VH contacts Peptide contacts
D1 1-7 W89 G91 R96 Y95H S100a S100b A2 E3 F4
4HIX W89 G91 R96 Y95H S100a S100b A2 E3 F4
A2 1-7 G91 T92 H93 F94   D1 E3 F4 R5 H6
4HIX G91 T92 H93 F94   D1 E3 F4 R5 H6
E3 1-7 F94 R96 W47 S50 R52 Y58 D1 A2 F4 R5
4HIX F94 R96 W47 S50 R52 Y58 D1 A2 F4 R5
F4 1-7 R96 G33 M34 S50 I51 R52 Y95 D1 A2 E3 R5
4HIX R96 G33 M34 S50 I51 R52 Y95 D1 A2 E3 R5
R5 1-7 D27d D28 Y32 G91 T92 Y95 A2 E3 F4 H6
4HIX D27d D28 Y32 G91 T92 R52 Y95 A2 E3 F4 H6
  1. Antigen contacting antibody residues revealed by the structure of 4HIX [24] is shown for comparison. Residues are numbered according to [36].