Figure 4

Conservation of Aβ and CDR loop conformation comparing 3D6 and humanized 3D6v1. A) Light chain CDR residues within 4 Å of antigen (some through water molecules which are not shown). 3D6 in purple, 4HIX structure [24] in green, antigen from both structures in red ribbon. B) Heavy chain CDR residues within 4 Å of antigen (some through water molecules which are not shown). 3D6 in purple, 4HIX structure in green, antigen from both structures in red ribbon. The dotted lines indicate hydrogen bonds. CDR, complementarity determining region.