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Table 2 Late-onset Alzheimer disease genome-wide association study: summary of results.

From: Genetics of Alzheimer disease in the pre- and post-GWAS era

  Non-ApoE hits ApoE-related hits
Reference Gene symbol P valuea Odds ratioa P valuea Odds ratioa
Grupe et al. [50] GALP, TNK1, chr14q32.13, PCK1, LMNA, PGBD1, LOC651924, chr7p15.2, THEM5, MYH13, CTSS, UBD, BCR, AGC1, TRAK2, EBF3 0.001 to 5.0 × 10-5 1.07 to 1.2 7.6 × 10-5 to 1.0 × 10-8 1.19 to 2.73
Coon et al. [51]     1.1 × 10-39 4.01
Reiman et al. [52] GAB2 9.7 × 10-11 4.06 - -
Li et al. [53] GOLPH2, chr9p24.3, chr15q21.2 9.8 × 10-3 to 4.5 × 10-6, b 0.46 to 3.23b 2.3 × 10-44 -
Abraham et al. [54] LRAT 3.4 × 10-6 to 6.1 × 10-7 1.2 to 1.3 4.8 × 10-6 to 4.0 × 10-14 -
Bertram et al. [55] chr14q31.2, chr19q13.41 6.0 × 10-6 to 2.0 × 10-6 1.1 to 1.4c 5.70 × 10-14 -
Beecham et al. [56] 12q13 3.40 × 10-7 - - -
Feulner et al. [57] MAPT, SORL1, CHRNB2, CH25H, GAB2, PGBD1, PCK1, LMNA 0.05 to 6.8 × 10-3 - <1.0 × 10-6 to <1.0 × 10-40 -
Poduslo et al. [58] TRPC4AP 3.85 × 10-10 to 5.63 × 10-11, c
0.03d
1.56d   
Carrasquillo et al. [59] PCDH11X 3.8 × 10-8
(0.08 to 5.4 × 10-13)e
1.29
(1.17 to 1.75)e
5.9 × 10-6 to
3.7 × 10-120
0.55 to 3.29
Harold et al. [60] CLU 8.5 × 10-10 (CLU) 0.86 (CLU) 3.4 × 10-8 to 1.8 × 10-157 0.63 to 2.5
  PICALM 1.3 × 10-9 (PICALM) 0.86 (PICALM)   
Lambert et al. [61] CLU 7.5 × 10-9 (CLU) 0.86 (CLU) 5.06 × 10-7 to <2 × 10-16 -
  CR1 3.7 × 10-9 (CR1) 1.21 (CR1)   
  1. The results of the 11 independent late-onset Alzheimer disease genome-wide association studies are depicted. The results from the original manuscripts shown in the table are (a) from all groups combined, (b) shown separately in each series, (c) from the discovery series, (d) from the follow-up case control series, and (e) variable based on different analytical models.