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Table 1 Demographics, cognitive test scores and CSF biomarker levels for the five genotypes (means with SD)

From: Performance on a pattern separation task by Alzheimer’s patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E 4 status and cerebrospinal fluid amyloid-β42 levels

ApoE
Genotype
n Age
Years
MMSE ADAS-Cog Picture recognition-pattern separation task Power of attention Aβ42 P-tau T-tau
      Difficult separations Easy separations msec    
      % Correct Speed % Correct Speed     
2/3 5 77 (10) 22 (5) 15 (8) 70 (28) 2,981 (3,137) 81 (15) 1,384 (443) 1,555 (296) 715 (113) 63 (17) 457 (147)
3/3 10 75 (9) 23 (4) 15 (10) 77 (26) 2,393 (1,450) 81 (17) 1,774 (1639) 1,621 (596) 536 (316) 76 (27) 555 (214)
4/2 2 75 (10) 26 (1) 9 (1) 79 (0) 1,078 (280) 86 (10) 1,099 (262) 1,430 (326) 439 (256) 66 (35) 535 (274)
4/3 28 76 (6) 25 (4) 13 (7) 82 (21) 1,830 (1,197) 82 (24) 1,483 (972) 1,504 (459) 414 (179) 99 (45) 748 (395)
4/4 5 70 (6) 22 (3) 19 (3) 44 (24) 4,263 (5,567) 84 (11) 2,132 (1,621) 1,579 (457) 295 (60) 97 (12) 769 (146)
  1. ADAS-cog, Alzheimer’s Disease Assessment Scale – cognitive subscale; ApoE, apolipoprotein E; CSF, cerebrospinal fluid; MMSE, mini–mental state examination.