| |
Covariates
|
|---|
|
Progression Measures
|
Age
|
Sex (1 = male, 0 = female)
|
Education
|
AMNART
|
Delusions
|
Hallucinations
|
Extra-pyramidal Signs
|
APOE Genotype
|
|---|
|
ADAS-Cog
|
-0.962 (.067)
|
NS
|
0.291 (.055)
|
-0.229 (<.001)
|
2.914 (.001)
|
NS
|
NS
|
NS
|
|
VSAT Time
|
-1.493 (<.001)
|
NS
|
NS
|
-2.339 (.001)
|
NS
|
NS
|
NS
|
NS
|
|
VSAT Errors
|
-0.179 (<.001)
|
NS
|
NS
|
-0.272 (<.001)
|
NS
|
NS
|
NS
|
NS
|
|
SCDR
|
NS
|
NS
|
NS
|
NS
|
1.386 (<.001)
|
1.245 (.003)
|
NS
|
NS
|
|
IADL
|
NS
|
-2.109 (<.001)
|
NS
|
NS
|
2.762 (<.001)
|
1.619 (.008)
|
NS
|
NS
|
|
PSMS
|
0.037 (.055)
|
NS
|
NS
|
NS
|
1.509 (<.001)
|
1.945 (.009)
|
NS
|
NS
|
- *Betas calculated in models adjusted for baseline severity, duration, pre-progression rate × time, pre-progression × time squared (if applicable), and other covariates that achieved the selection criterion of P < 0.10. NS means the covariate did not achieve the criterion of P < .10, or did not retain this significance level when included in the full model.
- ADAS-Cog = Alzheimer's disease Assessment Scale-Cognitive Subscale; AMNART = American version of the New Adult Reading Test; CDR-SB = Clinical Dementia Rating Scale Sum of Boxes; IADL = Instrumental Activities of Daily Living scale; PSMS = Physical Self-Maintenance Scale; VSAT = Verbal Series Attention Test.
