Table 4 Noncompartmental pharmacokinetics in plasma following single dosing with GSK933776 a
Geometric mean (CV in %) | ||||||
|---|---|---|---|---|---|---|
Parameters | 1 mg/kg ( N/n = 6/6) | 95% CI | 3 mg/kg ( N/n = 6/6) | 95% CI | 6 mg/kg ( N/n = 6/6) | 95% CI |
AUC0–12 (h∙mg/ml) | 0.2 (26.0) | 0.1 to 0.2 | 1.0 (19.5) | 0.9 to 1.3 | 1.6 (20.6) | 1.3 to 2.0 |
AUC0–t (h∙mg/ml) | 3.3 (39.3) | 2.2 to 4.9 | 23.0 (12.8) | 20.2 to 26.3 | 36.3 (15.3) | 31.0 to 42.6 |
Cmax (μg/ml) | 18.4 (29.0) | 13.6 to 24.9 | 104.0 (20.0) | 84.4 to 128.1 | 158.2 (24.0) | 123.8 to 202.1 |
Ct (μg/ml) | 0.5 (366.0) | 0.1 to 2.5 | 1.2 (33.0) | 0.9 to 1.7 | 1.5 (30.0) | 1.1 to 2.1 |
tlast (h) | 909.8 (105.5) | 367.0 to 2,255.4 | 1,337.4 (0.2) | 1,335.1 to 1,339.8 | 1,417.2 (7.0) | 1,317.6 to 1,524.3 |
tmax (h) | 11.7 (264.1) | 2.6 to 53.1 | 2.1 (16.4) | 1.8 to 2.5 | 1.9 (61.2) | 1.1 to 3.4 |