|
Parameters
|
Median (range)
|
|---|
| |
1 mg/kg ( N/n = 6/3)
|
3 mg/kg ( N/n = 6/6)
|
6 mg/kg ( N/n = 6/4)
|
|---|
|
AUC0–4 (h∙mg/ml)
|
0.0 (0.0 to 71.1)
|
0.0 (0.0 to 32.1)
|
0.0 (0.0 to 38.9)
|
|
AUC5–12 (h∙mg/ml)
|
87.9 (12.7 to 134.9)
|
54.8 (6.3 to 398.8)
|
140.2 (49.1 to 626.5)
|
|
AUC0–12 (h∙mg/ml)
|
87.9 (12.7 to 210.9)
|
54.8 (6.3 to 456.0)
|
140.2 (49.1 to 703.9)
|
|
AUC0–t (h∙mg/ml)
|
6.3 (0.0 to 339.5)
|
54.8 (6.3 to 456.0)
|
88.1 (0.0 to 703.9)
|
|
Cmax (μg/ml)
|
12.7 (0.0 to 47.8)
|
20.1 (12.5 to 84.1)
|
28.5 (0.0 to 116.9)
|
|
Ct (μg/ml)
|
19.0 (11.4 to 25.3)
|
19.6 (12.5 to 84.1)
|
47.9 (18.6 to 116.1)
|
|
tmax (h)
|
10.0 (2.0 to 11.0)
|
11.8 (10.0 to 12.0)
|
12.0 (11.0 to 12.0)
|
|
tlast (h)
|
17.0 (11.0 to 19.0)
|
12.0 (11.6 to 12.0)
|
12.0 (12 to 12)
|
|
tlag (h)
|
8.0 (0.0 to 10.0)
|
8.5 (2.0 to 11.0)
|
5.0 (2.0 to 8.0)
|
- aAUC0–4: Area under the cerebrospinal fluid (CSF) concentration–time curve from time 0 to 4 hours postdosing; AUC0–12: Area under the CSF concentration–time curve from time 0 to 12 hours postdosing; AUC5–12: Area under the CSF concentration–time curve from 5 to 12 hours postdosing; AUC0–t: Area under the CSF concentration–time curve to the last quantifiable concentration; Cmax: Maximum CSF concentration; Ct: Concentration at tlast; N: Number of patients who received GSK933776; n: Number of patients from whom quantifiable CSF pharmacokinetics concentration levels were obtained and analysed; tlast: Time of the last observed CSF concentration; tmax: Time of occurrence of Cmax; tlag: Time prior to the first measurable (that is, nonzero) concentration in CSF.
