|
Sampling time (h)
|
GSK933776 (n = 6/dose)
|
Baselineb
|
Postdosing
|
Change (%)
|
95% CI
|
|---|
|
0 to 4
|
1 mg/kg
|
363.4 ± 60.1
|
350.2 ± 61.7
|
−3.6
|
(−10.8 to 3.6)
|
| |
3 mg/kg
|
479.2 ± 65.8
|
446.4 ± 70.8
|
−6.8
|
(−14.9 to 1.2)
|
| |
6 mg/kg
|
502.7 ± 71.1
|
456.1 ± 88.9
|
−9.7
|
(−15.4 to −3.9)
|
|
5 to 12
|
1 mg/kg
|
363.4 ± 60.1
|
333.9 ± 52.1
|
−7.9
|
(−12.6 to −3.2)
|
| |
3 mg/kg
|
479.2 ± 65.8
|
428.9 ± 77.1
|
−10.7
|
(−20.2 to −1.2)
|
| |
6 mg/kg
|
502.7 ± 71.1
|
433.5 ± 85.1
|
−14.2
|
(−19.8 to −8.6)
|
|
0 to 12
|
1 mg/kg
|
363.4 ± 60.1
|
340.6 ± 55.7
|
−6.2
|
(−11.2 to −1.1)
|
| |
3 mg/kg
|
479.2 ± 65.8
|
435.7 ± 74.4
|
−9.2
|
(−17.9 to −0.5)
|
| |
6 mg/kg
|
502.7 ± 71.1
|
442.2 ± 86.4
|
−12.5
|
(−18.0 to −7.0)
|
- aCI: confidence interval. Results are reported as means ± standard deviations. b-6 to −1 hours predosing.
