From: TMEM106B expression is reduced in Alzheimer’s disease brains
Case number | IHC | qPCR/WB | Cause of death | Brain weight (grams) | Postmortem interval (hours) | Braak staging (amyloid deposition/neurofibrillary degeneration) | pTDP-43 immunoreactivity | p.T185S genotype | |
---|---|---|---|---|---|---|---|---|---|
Frontal cortex | Hippocampus | ||||||||
NC1 | + | + | Acute myocardial infarction | 1,130 | 1.4 | A/II | – | – | T/T |
NC2 | + | + | Acute myocardial infarction | 1,350 | 1.6 | 0/II | – | – | T/S |
NC3 | + | + | Lung cancer | 1,060 | 3.9 | A/II | – | – | T/S |
NC4 | + | + | Dissecting aortic aneurysm | 1,400 | 4.8 | A/I | – | – | T/T |
AD1 | + | + | Pneumonia | 1,000 | 1.1 | C/VI | + | + | T/S |
AD2 | + | Pneumonia | 1,230 | 14 | C/VI | T/S | |||
AD3 | + | + | Pneumonia | 1,220 | 10.5 | C/VI | – | + | T/S |
AD4 | + | + | Pneumonia | 1,240 | 8.1 | C/VI | – | – | T/S |
AD5 | + | + | Lung cancer | 1,090 | 4.5 | C/VI | – | – | T/T |
AD6 | + | + | Pulmonary infarction | 840 | 3 | C/VI | – | + | T/S |
AD7 | + | Respiratory failure by aspiration | 1,200 | 3.8 | B/IV | T/S | |||
AD8 | + | Pneumonia | 1,060 | 8 | C/VI | – | + | ||
PD1 | + | Pneumonia | 1,330 | 9.5 | B/IV | S/S | |||
PD2 | + | + | Pneumonia | 1,130 | 2.5 | B/II | – | – | T/S |
PD3 | + | + | Respiratory failure by aspiration | 910 | 2.5 | B/II | – | – | T/S |
PD4 | + | Colon cancer | 1,430 | 4 | A/I | S/S | |||
PD5 | + | Pneumonia | 1,320 | 9.3 | C/III | – | – | ||
ALS1 | + | + | Respiratory failure | 1,480 | 10.5 | 0/0 | – | – | T/S |
ALS2 | + | + | Respiratory failure | 1,090 | 1.3 | 0/I | + | + | T/T |
ALS3 | + | + | Respiratory failure | 1,560 | 3 | 0/I | + | + | T/S |
ALS4 | + | + | Respiratory failure | 1,320 | 10 | 0/II | + | – | S/S |
ALS5 | + | Respiratory failure | 1,360 | 2.5 | B/I | T/S | |||
ALS6 | + | Respiratory failure | 1,600 | 13 | B/I | T/S | |||
MSA1 | + | Pneumonia, septicemia | 1,040 | 1.5 | 0/I | – | – | ||
MSA2 | + | Pneumonia | 1,090 | 12 | A/I | – | – |