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Table 1 Demographic profile of the cases examined in the present study

From: TMEM106B expression is reduced in Alzheimer’s disease brains

Case number IHC qPCR/WB Cause of death Brain weight (grams) Postmortem interval (hours) Braak staging (amyloid deposition/neurofibrillary degeneration) pTDP-43 immunoreactivity p.T185S genotype
        Frontal cortex Hippocampus  
NC1 + + Acute myocardial infarction 1,130 1.4 A/II T/T
NC2 + + Acute myocardial infarction 1,350 1.6 0/II T/S
NC3 + + Lung cancer 1,060 3.9 A/II T/S
NC4 + + Dissecting aortic aneurysm 1,400 4.8 A/I T/T
AD1 + + Pneumonia 1,000 1.1 C/VI + + T/S
AD2   + Pneumonia 1,230 14 C/VI    T/S
AD3 + + Pneumonia 1,220 10.5 C/VI + T/S
AD4 + + Pneumonia 1,240 8.1 C/VI T/S
AD5 + + Lung cancer 1,090 4.5 C/VI T/T
AD6 + + Pulmonary infarction 840 3 C/VI + T/S
AD7   + Respiratory failure by aspiration 1,200 3.8 B/IV    T/S
AD8 +   Pneumonia 1,060 8 C/VI +  
PD1   + Pneumonia 1,330 9.5 B/IV    S/S
PD2 + + Pneumonia 1,130 2.5 B/II T/S
PD3 + + Respiratory failure by aspiration 910 2.5 B/II T/S
PD4   + Colon cancer 1,430 4 A/I    S/S
PD5 +   Pneumonia 1,320 9.3 C/III  
ALS1 + + Respiratory failure 1,480 10.5 0/0 T/S
ALS2 + + Respiratory failure 1,090 1.3 0/I + + T/T
ALS3 + + Respiratory failure 1,560 3 0/I + + T/S
ALS4 + + Respiratory failure 1,320 10 0/II + S/S
ALS5   + Respiratory failure 1,360 2.5 B/I    T/S
ALS6   + Respiratory failure 1,600 13 B/I    T/S
MSA1 +   Pneumonia, septicemia 1,040 1.5 0/I  
MSA2 +   Pneumonia 1,090 12 A/I  
  1. The demographic profile of the cases processed for immunohistochemistry (IHC), quantitative reverse transcriptase-polymerase chain reaction (qPCR), and western blotting (WB) is shown with the case number, the cause of death, brain weight, the postmortem interval, the Braak staging (amyloid deposition/neurofibrillary degeneration), phosphorylated TAR DNA-binding protein-43 (pTDP-43) immunoreactivity in the frontal cortex and the hippocampus, and the p.T185S genotype of the rs3173615 single nucleotide polymorphism. AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; MSA, multiple system atrophy; NC, non-neurological causes; PD, Parkinson’s disease.