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Table 1 Histone deacetylase 6 inhibition decreases total tau levels but not pathological tau

From: Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

Phosphorylation site Saline Tubastatin P value Source
Ser202/Thr205 (AT8) 0.8 ± 0.1 0.7 ± 0.1 0.46 Ana Spec, EGT group, Fremont, CA, USA
Ser396 0.5 ± 0.1 0. 6 ± 0.1 0.34 Ana Spec, EGT group, Fremont, CA, USA
Ser199/202 0.4 ± 0.1 0.5 ± 0.1 0.25 Ana Spec, EGT group, Fremont, CA, USA
Gallyas stain (NFTs) 1.3 ± 0.2 1.7 ± 0.4 0.21 Fischer scientific, Waltham, MA, USA
Total tau (H150) 2.2 ± 0.4 1.0 ± 0.2 0.03 Santa Cruz Biotechnology, Inc. Dallas, Texas, USA
  1. Mean ± SEM and P values are indicated for immunopositive p-tau stain in the rTg4510 saline-treated versus tubastatin-treated animals. Student’s t test, n = 6. NFT, neurofibrillary tangle.