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Figure 5 | Alzheimer's Research & Therapy

Figure 5

From: Assessing THK523 selectivity for tau deposits in Alzheimer’s disease and non–Alzheimer’s disease tauopathies

Figure 5

THK523 does not bind to Lewy bodies in Parkinson’s disease patient. Microscopy of 5-μm serial sections from the substantia nigra of a Parkinson’s disease patient. The left image (α-syn shows the first of two serial sections. It immunostained with an α-synuclein antibody to detect Lewy bodies (LB) in the substantia nigra. The black arrows indicate the positioning of LBs. The same region of tissue was subsequently imaged for the adjacent sections, which were treated with THK523. The positions indicated by the black arrows in the left panel were transferred to the adjacent THK523 serial section and are indicated by the yellow arrows (THK523). The absence of fluorescence staining indicates that THK523 does not bind to α-synuclein containing Lewy bodies in the same tissue region. Tissue sections were imaged using a Zeiss microscope and an AxioCam digital camera at 5× original magnification.

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Alzheimer's Research & Therapy

ISSN: 1758-9193