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Figure 1 | Alzheimer's Research & Therapy

Figure 1

From: Assessing THK523 selectivity for tau deposits in Alzheimer’s disease and non–Alzheimer’s disease tauopathies

Figure 1

THK523 binds to neurofibrillary tangles in an Alzheimer’s disease patient. Microscopy of 5-μm serial sections from the hippocampus of a representative Alzheimer’s disease patient. The left image (tau) is the first of three serial sections. It is immunostained with tau polyclonal antibody to detect tau lesions in the hippocampus. The black arrow indicates the positioning of neurofibrillary tangles (NFTs). The positioning of the NFTs indicated by the black arrow was transferred to subsequent adjacent serial sections that were either stained with THK523 (middle image, THK523) or immunostained with a monoclonal antibody raised to amyloid-β (Aβ) to identify senile plaques in the tissue section (right image, Aβ). Fluorescence staining of THK523 (middle) appears to colocalise and resemble tau NFTs, indicated by the yellow arrow, in the absence of Aβ immunoreactivity in the same tissue region (right, red arrow). Tissue section images were obtained using a Zeiss microscope and an AxioCam digital camera (Carl Zeiss Microscopy, North Ryde, Australia). Scale bars, 100 μm.

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