From: Fyn kinase inhibition as a novel therapy for Alzheimer’s disease
Observation | Detail | References |
---|---|---|
Increased Fyn in AD | Co-localized with Tau | [29] |
Amyloid-beta activates Fyn | Oligomer specific and PrP mediated | |
Fyn impairs synapse | N-methyl-d-aspartate receptor and dendritic spine loss | |
Fyn interacts with Tau | Localizes and phosphorylates Tau | |
Fyn alters AD transgenics | Fyn loss protects and Fyn gain accelerates |