Stage III chronic traumatic encephalopathy. In stage III chronic traumatic encephalopathy, phosphorylated tau pathology is severe and widespread throughout the frontal, insular, temporal, and parietal cortices. The cortical epicenters and depths of the sulci often consist of confluent masses of neurofibrillary tangles (NFTs) and astrocytic tangles (A). The intervening cortices show advanced neurofibrillary degeneration (B). The nucleus basalis of Meynert shows dense NFTs (C). The amygdala (D) and hippocampus (E) show marked neurofibrillary pathology. CP-13-immunostained 50 μm tissue sections, some counterstained with cresyl violet. Scale bar = 100 μm. Adapted from .