Figure 6

Effect of near-infrared light on amyloid-beta and plaque pathology in APP/PS1 mice. (A), (B), (C), (D), (E), (F) Quantification of amyloid-beta (Aβ) 4G8 immunolabelling of amyloid plaques in the neocortex (A, B, C) and hippocampus (D, E, F), based on plaque burden (A, D) , plaque size (B, E) and number of plaques (C, F). All error bars indicate standard error of the mean. *P < 0.05, ***P < 0.001, ****P < 0.0001. (H), (I), (J), (K), (L), (M) Representative micrographs showing Aβ labelling with the 4G8 antibody (brown) in the neocortex (H, I, J) and hippocampus (K, L, M). Arrows indicate plaques. Scale bar = 100 μm; scale in (M) applies to all other micrographs. DG, dentate gyrus of hippocampus; NIr, near-infrared light; SLM, stratum lacunosum moleculare; WT, wildtype.