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Table 2 Biochemical and ultrastructural characteristics of Alzheimer’s disease and frontotemporal lobar degeneration tauopathies

From: Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

  Tau repeat Filaments (width) Periodicity Reference
AD 3R ≈ 4R PHF (10 to 20 nm) >> SF (~15 nm) 80 nm [6]
PSP 4R >3R SF (15 nm); rare twisted filament (15 to 30 nm) >100 nm [7]
CBD 4R >3R SF >> twisted filament (15 to 30 nm) 160 nm [8]
PiD 3R >4R SF (15 nm) >> twisted filament (15 to 30 nm) 160 nm [9]
  1. Abbreviations: AD – Alzheimer’s disease; PSP - progressive supranuclear palsy; CBD - corticobasal degeneration; PiD - Pick’s disease; PHF - paired helical filament; SF – straight filament; nm - nanometer