Skip to main content

Table 2 Biochemical and ultrastructural characteristics of Alzheimer’s disease and frontotemporal lobar degeneration tauopathies

From: Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

 

Tau repeat

Filaments (width)

Periodicity

Reference

AD

3R ≈ 4R

PHF (10 to 20 nm) >> SF (~15 nm)

80 nm

[6]

PSP

4R >3R

SF (15 nm); rare twisted filament (15 to 30 nm)

>100 nm

[7]

CBD

4R >3R

SF >> twisted filament (15 to 30 nm)

160 nm

[8]

PiD

3R >4R

SF (15 nm) >> twisted filament (15 to 30 nm)

160 nm

[9]

  1. Abbreviations: AD – Alzheimer’s disease; PSP - progressive supranuclear palsy; CBD - corticobasal degeneration; PiD - Pick’s disease; PHF - paired helical filament; SF – straight filament; nm - nanometer