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Figure 2 | Alzheimer's Research & Therapy

Figure 2

From: Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

Figure 2

Ultrastructural characterization of tau filaments in Alzheimer’s disease and frontotemporal lobar degeneration tau. (Top, left) Alzheimer’s disease (AD) tau fibrils form paired helical filaments typically observed in flame-shaped cytoplasmic inclusion. (Top, middle) Progressive supranuclear palsy (PSP) tau fibrils typically form straight filaments with rare twisted filaments, similar to corticobasal degeneration (CBD), that aggregate in less compact bundles associated with dense granular material. (Top, right) Pick’s disease (PiD) tau fibrils are mainly straight filaments with some loosely twisted wide filaments that aggregate in close proximity and can be associated with dense granular material. (Bottom, left) Electron micrograph of tau filaments from AD showing paired helical filaments (PHF) and straight filament (SF). Bar, 50 nm. (Bottom, right) Twisted filaments in PSP, CBD and PiD have longer periodicity. Bar, 100 nm. Arrows point at twists of filaments.

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