Skip to main content

Table 1 List of drugs

From: Potential synergy between tau aggregation inhibitors and tau chaperonemodulators

Tau aggregation inhibitors Family Mechanism Toxicity BBB permeability Other notes
AQ2S Anthraquinone β-sheet inhibitor Nontoxic Likely Laxative
Emodin Anthraquinone β-sheet inhibitor Nontoxic Likely Laxative
Daunorubicin Anthraquinone β-sheet inhibitor Nontoxic Likely Laxative
Mitoxantrone Anthraquinone β-sheet inhibitor Nontoxic Likely Laxative
Pixantrone Anthraquinone β-sheet inhibitor Nontoxic Likely Laxative
C11 Carbocyanine β-sheet inhibitor Low toxicity Likely  
N744 Carbocyanine β-sheet inhibitor Low toxicity Unknown  
PR-619 Diaminopyridine Hsp70 inhibitor Some toxicity Unknown  
17-AAG Natural product derivative Hsp90 inhibitor Some toxicity Permeable Low bioavailability
Geldanamycin Natural product Hsp90 inhibitor Highly toxic Not permeable Toxic
Hydroxytyrosol Natural product β-sheet inhibitor Nontoxic Permeable  
Novobiocin Natural product Hsp90 inhibitor Low toxicity Poorly permeable  
Oleuropein Natural product β-sheet inhibitor Nontoxic Not permeable  
Oleuropein aglyxone Natural product β-sheet inhibitor Nontoxic Unknown  
Radicicol Natural product Hsp90 inhibitor Some toxicity Poorly permeable Low bioavailability
Withaferin A Natural product Cdc37 inhibitor Some toxicity Permeable  
Paclitaxel Natural product Microtubule stabilizer Highly toxic Poorly permeable  
Curcumin Natural product; flavonoid Hsp70 inhibitor Nontoxic Permeable Low bioavailability
Myricetin Natural product; flavonoid Hsp70 inhibitor Low toxicity Permeable  
Quercetin Natural product; flavonoid Hsp70 inhibitor Low toxicity Permeable  
B1C11 N-Phenylamine β-sheet inhibitor Low toxicity Unknown  
B4A1 N-Phenylamine β-sheet inhibitor Low toxicity Unknown  
B4D3 N-Phenylamine β-sheet inhibitor Low toxicity Unknown  
B4D5 N-Phenylamine β-sheet inhibitor Low toxicity Unknown  
Methylene blue Phenothiazine Hsp70 inhibitor Low toxicity Permeable Blue color
Quinoxalines Phenothiazine Hsp70 inhibitor Selective toxicity Permeable Low bioavailability
BSc3094 Phenylthiazolyl-hydrazides β-sheet inhibitor Some toxicity Unknown  
Epalrestat Rhodanine β-sheet inhibitor Some toxicity Permeable Aldose reductase inhibitor
Troglitazone Rhodanine β-sheet inhibitor Highly toxic Likely  
MKT-077 Rhodocyanine Hsp70 inhibitor Selective toxicity Not permeable  
YM-01 Rhodocyanine Hsp70 inhibitor Selective toxicity Not permeable  
YM-08 Rhodocyanine Hsp70 inhibitor Selective toxicity Permeable Less potent than YM-01
Macrocycles Synthetic β-sheet inhibitor Unknown Unknown  
  1. 17-AAG, 17-(allylamino)-17-demethoxygeldamycin; AQ2S,anthraquinone-2-sulfonic acid; BBB, blood–brain barrier; C11,3,3′-diethyl-9-methyl-thiacarbocyanine iodide; Cdc37, celldivision control 37 kDa; Hsp, heat shock protein; MKT-077,1-ethyl-2-((3-ethyl-5-(3-methylbenzothiazolin-2-yliden))-4-oxothiazolidin-2-ylidenemethyl)pyridinium chloride; N744,3,3′-bis(β-hydroxyethyl)-9-ethyl-5,5′-dimethoxythiacarbocyanineiodide; PR619, 2,6-diamino-3,5-dithiocyanopyridine, thiocyanic acidC,C′-(2,6-diamino-3,5-pyridinediyl) ester;2,6-diaminopyridine-3,5-bis(thiocyanate).