| |
AD vs. NC (NC vs. AD)
|
MCI vs. NC (NC vs. MCI)
|
MCI vs. AD
|
|---|
|
Measure
|
Region
|
Effect size
|
Region
|
Effect size
|
Region
|
Effect size
|
|---|
|
Fractional anisotropya
|
Frontal lobes
|
-0.64(0.70)
|
Frontal
|
-0.51 (NS)
|
Frontal
|
0.29
|
| |
Temporal
|
-0.74(0.57)
|
Temporal
|
-0.46 (0.38)
|
Temporal
|
0.27
|
| |
parahippocampal
|
-0.67 (1.17)
|
Hippocampus (PHg)
|
-0.97 (0.97)
|
PCg
|
0.37
|
| |
PCg
|
-0.86(0.84)
|
PCg
|
-0.53 (0.65)
|
Genu
|
0.35
|
| |
Genu
|
-0.51(0.63)
|
Genu
|
-0.42 (0.41)
|
Splenium
|
0.51
|
| |
Splenium
|
-0.70(1.10)
|
Splenium
|
-0.60 (0.44)
| | |
| |
UF
|
-1.14(1.03)
|
SLF
|
-0.77 (NS)
| | |
| |
SLF
|
-0.85(0.77)
| | | | |
|
Mean diffusivityb diffusivityb
|
Frontal
|
0.50 (-0.75)
|
Temporal
|
0.55 (-0.40)
|
PCg
|
-0.40
|
| |
Temporal
|
0.73 (-0.89)
|
Parietal
|
0.86 (-0.69)
|
Genu
|
-0.32
|
| |
Parietal
|
0.72 (-1.03)
|
Genu
|
0.43 (-0.43)
|
Splenium
|
-0.04
|
| |
Occipital
|
0.47 (-0.67)
|
Splenium
|
0.63 (-0.46)
| | |
| |
Hippocampus
|
0.60 (-1.17)
|
PCg
|
0.32 (-0.26)
| | |
| |
PCg
|
0.69 (-0.74)
|
Hippocampus
|
1.08 (-1.0)
| | |
| |
Genu
|
0.50 (-0.67)
| | | | |
| |
Splenium
|
0.56 (-0.94)
| | | | |
| |
UF
|
0.66 (-0.72)
| | | | |
- Effect sizes are summarized per region [78, 79]. AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal controls; PCg, posterior cingulate gyrus; PHg, parahippocampal gyrus; SLF, superior longitudinal fasciculus; UF, uncinate fasciculus. aNegative effect size indicates abnormality and positive effect size indicates integrity of white matter. bPositive effect size indicates abnormality and negative effect size indicates integrity of white matter.
