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Table 4 Summary of brain regions showing statistically significant differences

From: Role of emerging neuroimaging modalities in patients with cognitive impairment: a review from the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012

  AD vs. NC (NC vs. AD) MCI vs. NC (NC vs. MCI) MCI vs. AD
Measure Region Effect size Region Effect size Region Effect size
Fractional anisotropya Frontal lobes -0.64(0.70) Frontal -0.51 (NS) Frontal 0.29
  Temporal -0.74(0.57) Temporal -0.46 (0.38) Temporal 0.27
  parahippocampal -0.67 (1.17) Hippocampus (PHg) -0.97 (0.97) PCg 0.37
  PCg -0.86(0.84) PCg -0.53 (0.65) Genu 0.35
  Genu -0.51(0.63) Genu -0.42 (0.41) Splenium 0.51
  Splenium -0.70(1.10) Splenium -0.60 (0.44)   
  UF -1.14(1.03) SLF -0.77 (NS)   
  SLF -0.85(0.77)     
Mean diffusivityb diffusivityb Frontal 0.50 (-0.75) Temporal 0.55 (-0.40) PCg -0.40
  Temporal 0.73 (-0.89) Parietal 0.86 (-0.69) Genu -0.32
  Parietal 0.72 (-1.03) Genu 0.43 (-0.43) Splenium -0.04
  Occipital 0.47 (-0.67) Splenium 0.63 (-0.46)   
  Hippocampus 0.60 (-1.17) PCg 0.32 (-0.26)   
  PCg 0.69 (-0.74) Hippocampus 1.08 (-1.0)   
  Genu 0.50 (-0.67)     
  Splenium 0.56 (-0.94)     
  UF 0.66 (-0.72)     
  1. Effect sizes are summarized per region [78, 79]. AD, Alzheimer's disease; MCI, mild cognitive impairment; NC, normal controls; PCg, posterior cingulate gyrus; PHg, parahippocampal gyrus; SLF, superior longitudinal fasciculus; UF, uncinate fasciculus. aNegative effect size indicates abnormality and positive effect size indicates integrity of white matter. bPositive effect size indicates abnormality and negative effect size indicates integrity of white matter.